Can infections trigger alpha-synucleinopathies?

[aspergerian]

Can infections trigger alpha-synucleinopathies? - 2019 - NCBI.

ncbi.nlm.nih.gov/pubmed/316...

Vagus nerve infection hypothesis - MEpedia.

me-pedia.org/wiki/Vagus_ner...

[pvw2]

So, is it the infection or the antibiotics? It's difficult to separate these in the statistics of today's medicine.

[Rosenmu in reply to pvw2]

From my research, I believe they both cause issues, especially in the gut. Although antibiotics are taken for the infection, virus, whatever, they can make the gut and body susceptible to even more infections, viruses and parasites which can damage the alpha synuclein. Antibiotics also damage the mitochindria, so do many other drugs, we need healthy mito for energy. Toxins also damage the alpha synuclein and Mito, especially if it is surrounded by a toxic system, it seeps into the cell.

The transfer of damaged alpha synuclein via the vagus nerve is no longer a hypothesis from what I have seen in the research.

[pvw2 in reply to Rosenmu]

Glad to hear people are working on making sense of the data, but I always like to ask questions. I remember the first data that came out comparing Tylenol to aspirin and without a control group claimed Tylenol caused blood clots. I turned to my uncle, good at statistics, and said, "I bet Tylenol doesn't cause blood clots, but aspirin prevents them." His response, "How can you said that." My reply, "Because they didn't have a control group." His reply, "Yes, they need a control group." Later studies found that aspirin was actually a blood thinner.

You do have a consistent view of the data that hopefully will help to find a cure.

[Rosenmu in reply to pvw2]

Dr Datis Kharrzzin is an awesome source of info and very good at connecting the dots and an excellent researcher. I've learned a lot from him and the recent Mitochondria Summit.

[aspergerian]

From Tulisiak CT et al 2019:

ncbi.nlm.nih.gov/pubmed/316...

Visceral organs innervated by the vagal nerve, including the gut and the liver, could constitute other peripheral sites that may be impacted by infections, subsequently triggering PD. In this case, infections in visceral organs could potentially first affect neurons in the enteric nervous system (ENS) and spread to the brain by traveling up the vagus nerve, ultimately triggering central PD pathology (Fig. 1B). In line with this, epidemiological studies have shown that both vagotomy and appendectomy are associated with decreased risk of developing PD, in particular if the surgery takes place early in life.74–76.