Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease. - probiotics - NCBI

[aspergerian]

RESULTS:

Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin-1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin-1α and CXCL8 and also revealed increased interleukin-1β and C-reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration.

CONCLUSIONS:

Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society.

ncbi.nlm.nih.gov/pubmed/295...

Also:

Probiotics May Have Beneficial Effects in Parkinson's Disease: In vitro Evidence.

2019.

ncbi.nlm.nih.gov/pubmed/311...

Probiotics in Extraintestinal Diseases: Current Trends and New Directions.

2019.

ncbi.nlm.nih.gov/pubmed/309...

[aspergerian]

Consumption of probiotics or probiotic yogurt was associated with significantly higher levels of three analytes, TARC (CCL17), IL-7, and MIP-1β, regardless of disease status (Supp Fig 5a), but an additional eight factors were significantly elevated only in PD patients taking probiotics (Supp Fig 5b). Most of the analytes affected by probiotic use were chemokines.

From first cite in this thread.