Norman Lamb, exenatide and medicinal cannabis

[Ianfrizell]

Hi all

This is a link to my vlog about my meeting with Norman Lamb MP to discuss the prescription of exenatide and medicinal cannabis.

youtu.be/q2J2x6pVE3o(Not working as expected?)

Cheers,

Ian

[Seamus6]

Persistence is the enemy of failure, keep plugging away and keep us posted.

I sense Exenatide is not far away from being available, thanks to people like you for constantly pushing ☺️

Almost makes me wish I had diabetes then I could be prescribed it🤔

[Astra7]

The whole cannabis restriction is insane.

Can you get exanatide from Mexico or something? Will they not let you have it or just not pay for it?

You are looking well btw - are you trying something new?

Good luck with it all.

[PDConscience]

Bravo, well done!

[Farooqji]

Is Exenatide proven to be effective? I haven't come across any solid proof of that.

[WinnieThePoo in reply to Farooqji]

Depends what you mean by proven. It isn't clinically approved because the phase 3 trial hasn't yet started, let alone finished and concluded for approval. The small group phase 2 trial was a bit mixed in its results (and too short a trial period) but basically it appeared to confirm significantly slower progress of the motor symptoms. Both Dr Foltnie and Dr Athuda look like the cats that have got the cream on this one though.

content.iospress.com/articl...

discusses the results. In essence it seemed to slow progress of motor symptoms, but wasn't statistically significant for other outcomes. The sample size was small, the trial period short, the randomisation between placebo and drug group skewed (by hazard)

However, I'm a bit surprised by this Vlog. My understanding is the healthcare trust are correct. It's not just a question of paying for it - it's basically not authorised for use for the treatment of PD, even though it is authorised (and therefore presumably acceptably safe) for treatment of some cases of type 2 Diabetes.

drugs.com/uk/bydureon.html

And the trials don't support EMA authorisation for PD use. (I'll try to check this)

The same basic restriction applies here in France (and in the USA) too.

That said - I share Ian's conclusion that this drug looks promising, ( a near certainty) and if a practitioner is able to prescribe it for PD, even though not yet authorised for that purpose, I would be interested in having the opportunity to try it.

Isradipine is the other interesting drug on the cusp of announcing phase 3 results. That one I can get right now - and am exhibiting saintly patience waiting for the trial outcome. I think I can manage another couple of months. Not sure which may be the more promising

medicalnewstoday.com/articl...

Note - it is thought likely that other glp1 receptor agonists are even more effective in treating PD - particularly Liraglutide

[WinnieThePoo in reply to WinnieThePoo]

Just caught up with the link to Ians earlier Vlog about exanatide and off-label prescribing. Hope it goes well.

[WinnieThePoo]

Ian. Very interesting (as are all your Vlogs I've viewed - just a handful as I try to balance my PD obsession with the busy season at work). I have started a post about off-label medication and would be interested in your input. Richard