Inheritance pattern

[MGP201]

My paternal grandfather and aunt were diagnosed of PD. My father was not and he lived 80 years. How could I inherit PD?I am 50 years old.

[Hidden]

There is PD on both my mother's and father's side but it's all the way back to their grandparents and much older onset. I'm 47.

[GymBag]

From your mother

Seriously , the last information I got from 23and me was that the possibility of genetic inheritance being a cause of PD was very very very small .

Siblings with PD are usually explained by the fact that they lived in a common environment. But I was wrong once before, maybe they have discovered new possible genes that are causes. Lets see what the others say.

[Juliegrace]

My mother and her brother both have it, diagnosed in their late 60s. Mine started in my late 40s. My 23andme odds were high- it's been a long time, I think upwards of 40% probability- but I am Ashkenazi Jewish and the prevalence is very high. The research confirming heritability is very young and still developing. Even 8 years ago the common refrain was that PD was not hereditary.

[sharxno1]

Its a really interesting subject, I was diagnosed in 2011 at 41. My wife and I wanted kids so we asked to see a genetics specialist who looked into it and stated that because my wife didn't have PD we would be OK. Don't ask me why. In a nutshell its worth asking for a referral to the genetics specialist.

[alexask]

PD is a mixture of environmental and genetic factors. Environmental factors include introverted character, type 2 diabetes, taking statins, traumatic events leading to lack of sleep, pesticide exposure, exposure to heavy metals ( including mercury).

[BogaTamp]

Hope all is well today

[DianeF]

My neurologist told me they now think there are 14-17 genetic markers for Parkinson’s. 23 and Me told me I don’t have the two most common but they did not test for the others. But, I was raised on well water in a house in the valley of three hills which were populated with farms, so who knows what was in our water.