Zonisamide...new drug for Parkinson's?

[Blackfeather]

ncbi.nlm.nih.gov/pubmed/205...

[park_bear]

I did use Zonisamide for a while early on and it did seem to help with tremors. I didn't realize it did all these good things:

"effects on Parkinson's disease include activation of dopamine synthesis, inhibition of monoamine oxidase,... and markedly increases glutathione S-transferase levels in the striatum by enhancing the astroglial cysteine transport system "

Glutathione is what we are trying to enhance by taking NAC.

[Joanne_Joyce]

Ann Neurol. 2010 Feb;67(2):239-49. doi: 10.1002/ana.21885.

Neuroprotective effects of zonisamide target astrocyte.

These results provide new pharmacological evidence for the effects of ZNS. ZNS markedly increased GSH levels by enhancing the astroglial cystine transport system and/or astroglial proliferation via S100beta production or secretion. ZNS acts as a neuroprotectant against oxidative stress and progressive dopaminergic neurodegeneration.

[Blackfeather]

My doctor prescribed zonisamide for me, so we will see. I will let everyone here know my results. I'm excited about this drugs potential benefits.

[Carolinagirl123 in reply to Blackfeather]

hey, let me know how it goes!

[jaberalhddad]

Any updates from the users of zonisamide ?

onlinelibrary.wiley.com/doi...

[Blackfeather in reply to jaberalhddad]

I've had to hold off on taking zonisamide because I am trying to taper off of fentanyl pain patch, which will probably take about a month. Just didn't want to have to much to deal with at one time.