Georgetown's next Nilotinib-for-PD trial (i.e. Phase 2 trial) to start in January

[jeffreyn]

The new trial has just been announced on the ClinicalTrials.gov website.

It states, however, that recruitment has not yet commenced.

clinicaltrials.gov/ct2/show...

(hat tip to badboy99 at NeuroTalk for the link)

[jeffreyn]

I forgot to mention that I got an email from GU earlier this week. In the email they said that for their Nilotinib trials they will only be recruiting patients who live within 50 miles of Georgetown University Hospital in Washington DC.

[p-oui]

Thanks Jeffreyn,

Info on Inclusion Criteria:

Written informed consent

Capable of providing informed consent and complying with study procedures. Subjects who are unable to provide consent may use a Legally Authorized Representative (LAR).

Patients between the age of 40-90 years, medically stable

Diagnosis of PD according to the UK Brain Bank Diagnostic Criteria

PD subjects with MoCA ≥ 22

2.5 ≥Hoehn and Yahr stage ≤3

No mono-amine oxidase (MAO)-B inhibitors (Selegeline or rasagiline) are allowed at least 6 weeks before enrollment

Must be medically stable on 800mg Levodopa daily for at least 4 weeks

QTc interval 350-460 ms, inclusive

Participants must be willing to undergo LP at baseline and 12 months after treatment