I was diagnosed with PN 10 years ago. It initially started in my hands with tingling and numbness in my index fingers and thumbs. After having the carpel tunnel operation three times on each hand it was decided that I should see a neurologist who after several tests diagnosed hereditary neuropathy. Since then it has travelled up both legs and both arms together with numb buttocks. Recently it has travelled to my neck and lower jaw. I take pregabelin two times per day and amitriptyline at night. Some nights it is almost unbearable with my legs tinkling with a burning sensation and the same in my arms. I can't seem to find out what the future prognosis is. I know there is no cure. Will it affect the organs eventually?