expert opinion

[CherylJR]

I am curious if there are C3GN patients that don’t have a low C3.

Since being dx’d with Sjogrens, back to maybe SLE (after a second opinion read on my biopsy at Brigham and Womens looking more like C3GN and not lupus nephritis)…can you have this disease with a normal C3? So far, I have had a slight low C4 and slight low C1Q but normal C3 and all have rebounded back to normal at this point.

I am awaiting my results from the Smith lab.

This is all very new to me and scary. Thank you.

[DavidF_NKF Partner]

Hi CherylJR, thank you for your question. We have sent it to our Expert Panel. Please watch for a reply in about a week sor so.

[DavidF_NKF Partner]

Hi again, CherylJR,

Thank you again for your question on C3 levels. Here is the response from our Expert Panel:

"Approximately 30-40% of patients with C3G patients will have serum C3 levels in normal range, so the presence of a normal C3 level does not preclude the diagnosis, which can only be made by kidney biopsy."

We hope this is helpful.

[CherylJR in reply to DavidF_NKF]

thank you David