Who can explain?sarcoidosis liver( granuloma) and pbc wich one cause the other

[Mysa1981]

Who can explain?

sarcoidosis liver( granuloma) and pbc wich one cause the other

[Millie09]

wished I could help but I don't have either of them .I have cirrhosis from alcohol abuse many years ago .9 years I have been living with the disease .I would ask your health team

[Louisepeters]

I too am interested in any one who knows about this. I was diagnosed with sarcoidosis a few months before my liver problem was discovered. This turned out to be cirrhosis / HCC !! Very grateful for any answers, as I have not yet had any clear explanations as to what sarcoidosis actually is.

Thank you in advance and best wishes to all you courageous and a lot of members who I "admire".

Louise xxx

[AyrshireK]

This taken from a few other pages.

Sarcoidosis (sar-koy-DO-sis) is a disease of unknown cause that leads to inflammation. This disease affects your body’s organs.

Normally, your immune system defends your body against foreign or harmful substances. For example, it sends special cells to protect organs that are in danger.

These cells release chemicals that recruit other cells to isolate and destroy the harmful substance. Inflammation occurs during this process. Once the harmful substance is gone, the cells and the inflammation go away.

In people who have sarcoidosis, the inflammation doesn't go away. Instead, some of the immune system cells cluster to form lumps called granulomas (gran-yu-LO-mas) in various organs in your body.

PBC (Primary Biliary Cholangitis) is believed to be an autoimmune disease. This is a disease where the body attacks itself. In this case, the body’s defence against germs and infections – the immune system – mistakes the cells lining the bile ducts as ‘foreign’ and attacks them.

Perhaps and this is just an educated guess. You have an auto-immune condition which is throwing your immune system into an absolute tizzy. It is seeing the bile ducts as 'foreign' and attacking those leading to your PBC at the same time as it is in overdrive it's amassing all those immune response cells which are clumping together but not dispersing as described above in the sarcoidosis explanation. The inflammation isn't going away due to your ongoing PBC and therefore the immune cells are clustering together forming your granulomas. Same way as in Louisepeters case your immune system was fighting the HCC in your liver.

Hope that explains things a bit - just an educated guess on my part.

Katie

[Louisepeters in reply to AyrshireK]

Wow ! Katie you are a blessing. Have asked so many doctors to explain. I was diagnosed 2006 and with HCC / Cirrhosis 2007. Always get an answer in the "medical language" and the explanations on search machines are not much more clearer. Thank you so much. Are you in medical practice ? You certainly have helped a lot. Thank you again and all the best.

Love

Louise xx

[AyrshireK in reply to Louisepeters]

Not a medic just seem to find my way to t'interweb pages that put things into 'clearer speak' ...........spent 5 years supporting hubby and translating so much med speak for him as we travel his liver journey.

Katie x