Prolia

[Sunnygirl69]

How long does it take for Prolia (denosumab) to fully leave your system? That is, as if you had never taken.

[Girlguides]

I've had 3 denosumab injections ans due 4th in March.I'm hesitant to have this as I've had a lot of neck and back pain.

I believe I will have to go on another medication because of more spine fractures. Due to stopping prolia. I dont know how long it takes to leave your body

Very worried and anxious.

[ABwn in reply to Girlguides]

May I ask if you had fractures before taking prolia? I've read of others stopping. Good luck.

[Girlguides in reply to ABwn]

Yes I had 3 spine fractures. That's the reason for going on Prolia.Thanks fir reply.

[ABwn in reply to Girlguides]

Did your specialist ask you to stop or was it your decision? I have pain due to the fractures I caused by a fall and only after I had an MRI to see how bad and where they were. Then I was put on Prolia. 🤔 Never quite sure what is the best. Take care.

[Girlguides in reply to ABwn]

I haven't stopped yet. I will make an appointment for blood test this week then will get an appointment at the hospital.I've told them about the neck and back pain previously but am told not the injection.!!

You also take care

[ABwn in reply to Girlguides]

So this means that the rheumatology specialist told you not to take? Or your GP? Medications can be so confusing!!🫢

[Boneness in reply to Girlguides]

I am holding back on my first injection of Prolia, as I have read so much concerns about the rebound if you need to come off it! It is very alarming reading. I have neck and back pain already, without having had any of the injections. I am in pause mode presently after being taken off the yearly infusions, because it had stopped working after 4 years. I really do not want to agree to Prolia, but it looks like there is nothing else that is suitable sadly. I had Bonviva some years ago but could not tolerate it.

[Siamang]

only had the 1 prolia shot and was told around 5 months. My symptoms went by 3-4 mths.

[questionably]

Half life for Prolia is 32 days. It takes 4 to 5 months for Prolia to leave your system.

[questionably in reply to questionably]

Prolia sets up a process that can continue to affect your bones for about 2 years. You lose the bone you've gained rapidly starting in the first weeks after stopping Prolia. Without preserving the gain and preventing rebound your bones will be worse than if you'd never taken Prolia. If you manage (through Reclast) to preserve that bone, you might always be advantaged by having taken Prolia. I'm guessing that it is rebound that you are concerned with. It is thought that the risk of fracture from rebound can continue for two years.

[Posy-White]

Hello Sunnygirl69

In June 2017, the UK and Europe had not taken on the recommendation from the manufacturers of Prolia to go onto an alternative medication to ‘lock in’ any gains made in bone density by having Prolia and to prevent any possible rebound fractures and rapid loss of bone density. It slowly filtered through to hospitals from September 2017.

In June 2017 I had been on Prolia for 5 years, the June Dexa scan showed I was no longer in the Osteoporosis range, but mid range on the scale for Osteopenia, I wasn’t that happy about having no medication, but was assured that I’d still be monitored every 6 months with blood tests etc, I fussed a bit ut was told I could be prescribed a medication for Osteoporosis has I no longer had it. (When I started Prolia in 2012 I lived in London and attend one of the big teaching hospitals, in 2014 we moved and the local hospital was small )

In October 2017, 4 months after stopping Prolia I had 8 spinal fractures, I am disabled as a result of the fractures. The only fracture before this was one bone in my foot after a road accident on my bicycle, I've not had any since.

You might find this hard to believe but after a two year course of daily injections of Forsteo, then a year of an Infusion of Zoledronic acid, which didn’t suit me I went back on to Prolia in 2021. In 2024 when I had my last Dexa Scan (This didn’t include the areas of spine badly damaged) but appart from my R hip and damage parts of my spine I have at last got back into the Osteopenia range. If Prolia is suitable it does work, however if it doesn’t suit please don’t just stop the risk is too great, there is lots of advice on the ROS website about the different medications – how they are supposed to work and side effects some people have had.

I do hope you, Boneness and Abwn are able to find a medication that suits, it is such a stressful thing as it is in the end down to us to say yes or no.

Best Wishes

Posy White