Denosumab and AF

[spikynana]

Hi, I had a minimally invasive mitral valve repair plus a cryomaze proceedure in June this year. I was doing really well and had had no episodes of AF. I have osteoporosis in my spine and hip and had received 3 yearly infusions of Zelondronate. I was hopeful that this would have been successful. Anyway, I visited the Robert and Agnes Hunt Orthopaedic Hospital in September and my Dexa scan showed no improvement in my spine and a worsening in my hip. I was told as my osteoporosis is severe (even though I have never broken a bone) and I would have to have more treatment. I had read that zelondronate can cause heart arrythmias so I was keen not to risk that. Denosumab 6 monthly injections were suggested as I am unable to tolerate bisphosphonates. Less than a week later I had a heart rate of 150 and AF on a treadmill assessment at cardiac rehab. This was followed by a chest infection. The exact same thing has now happened on the treadmill 3 times at cardiac rehab and an episode of AF following a walk up hill to my house. I have been referred back to my surgeon Mr Paul Modi as he is concerned. Has anyone else experienced problems with Denosumab? This seems to me to be too much of a coincidence! I am 63.

[10gingercats]

In my opinion this Denosumab has been dished out a bit too readily.It was pressed on me when I had a hip replacement due to an unfortunate accident not osteroporosis linked. I refused and continue to take calcium and vit D .Others I know of have had similar experiences.So do be advised by your cardiologist who should be raising the issue on your behalf with your Denosumab provider.

[spikynana in reply to 10gingercats]

Thank you for your comment. I should have an appointment soon with my cardiologist and I will certainly be bringing it up.

[Rajeshrnair]

Hello spikynana,

Hope everything went fine with you.

Wish you a quick recovery.

All the best