Looking for Update trodusquemine

[arkhan53]

Any current update regarding trodusquemine treatment for plaque reversal in artries?

[MichaelJH Heart Star]

My understanding is that it is still undergoing trials for the treatment of obesity and Type II diabetes. These conditions can lead to irritation of the arteries often leading to plaque formation.

I personally doubt that it will be a magic bullet to zap arterial plaque but more a tool in halting or slowing the progression of arterial disease.

Having read your bio I think you need to talk with your cardiogist to discuss the options. Some people do well on medication and lifestyle changes. I will try and find the reference for you.

[arkhan53 in reply to MichaelJH]

Thanks. My Doc suggested for bypass surgery after having 2nd angiography in this year after 4 years. But my stance is that if my original artries get blocked progressively in 4 years, how can an other patch protect the formation of plaque again. So I am looking for alternate.

[Chappychap in reply to arkhan53]

You're right to think carefully about bypass surgery, it's a major operation with large risks, but even larger potential rewards.

However, I'm not so sure about the idea that your atherosclerosis formed over just four years. In reality most plaque formation takes a very, very long time. It's just that in the early stages (which can last for decades) it's almost undetectable, then in the later stages it accelerates and begins to be more visible. A successful bypass operation could give you twenty or more years of angina free, active life.

There is currently no medication (nor life style change) that are proven to reverse your atherosclerosis, so the only alternative to bypass surgery is to live a life progressively more restricted by angina. I accept that for some patients this is still a better option than bypass surgery, however it sounds as if your cardiologist doesn't believe this is the case with you, and for you the fresh start and second chance that a successful bypass operation can deliver might be possible.

[MichaelJH Heart Star]

Here's one of the references I was referring to earlier :

nih.gov/news-events/news-re...

As Chappychap has said it is your decision of you have a bypass. Before my bypass my quality of life was very low. A former colleague's father had a bypass decades ago and is doing well in his nineties over 40 years later. My personal opinion is go for it but ensure you make the lifestyle changes.