Statins/Anti-coagulants/Dementia

Hi

Does anyone here have an opinion or information on the correlation between statins/esomeprazole and dementia. I have read a number of academic papers outlining the increased risk of cognitive impairment in patients who take statins/omeprazole and anti-coagulants. GPs tend not to commit to commenting on the subject. But I was told that by the time dementia was diagnosed it would be too late to care!!

I would be interested to know others opinions, especially from medical professionals.

2 Replies

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  • Hi there,

    interesting, I looked on the Alzheimer Society website for their studies. There is an article here alzheimers.org.uk/info/2001..., which suggests a reduced risk of dementia with the use of statins. There is ongoing research in this area and also vascular dementia.

    There is also an article in an EU journal, here thesynapse.eu/medical-news-..., which seems to indicate that delayed use of anti-coagulants actually increases the dementia risk.

    On the counter argument side research undertaken in Utah, woodstreetclinic.com/home/b... shows an increased risk with the use of warfarin and dementia but this is more concern for AF sufferers.

    As with most drugs there are side effects, some terrible others more benign. the days are long gone when any old drug could be issued without stringent testing taking place

  • Hi,

    Thank you for your enquiry. I have discussed this with medical colleagues who have suggested you may benefit from reading Professor Rory Collins Cholesterol Trialists group. They undertook a review of the data last year (2016) – and reported in their paper in the Lancet – “Nor were there differences between the treatment groups in the numbers of participants reported to have developed dementia during follow-up (31 [0·3%] vs 31 [0·3%]), albeit that the numbers of events were small.”

    There is nothing mentioned in the British National Formulary to show a correlation between the two or with regards to anticoagulants or esomeprazole.

    It is plausible that taking a statin will reduce your risk of developing vascular dementia, but a Cochrane review found that statins given in late life to people at risk of vascular disease did not reduce risk. “There is good evidence that statins given in late life to people at risk of vascular disease do not prevent cognitive decline or dementia. Biologically, it seems feasible that statins could prevent dementia due to their role in cholesterol reduction and initial evidence from observational studies was very promising. However, indication bias may have been a factor in these studies and the evidence from subsequent randomised control trials (RCTs) has been negative. There were limitations in the included studies involving the cognitive assessments used and the inclusion of participants at moderate to high vascular risk only.” (Bernadette McGuinness , David Craig , Roger Bullock and Peter Passmore - Online Publication Date: January 2016).

    The evidence does not support the proposition that there is a link between taking a statins and developing dementia.

    Take care,

    Emily

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