Hi Are there any alternatives to lansoprazole and omeprazole? Previously taking PPI omeprazole for acid reflux but was worried as american research stated link between heart disease and strokes (both in family) with prolonged use of these drugs so GP prescribed ranitidine but it is not as effective. Have been ill for 9 weeks with shortness of breath. 3 lots of pred did not shift it but started taking lansoprazole and I was better within 1 day. Any advice greatly appreciated.