When news about a novel coronavirus switched from a chronicle of its progress in China to headlines about a worldwide COVID-19 pandemic, Gladstone Institutes scientist Nadia Roan, PhD, was in the midst of publishing several papers on T cells and their role in HIV spread and long-lasting infections.
Aside from serving as HIV targets and hideouts, T cells are an important part of the body’s immune response against many viruses. They are also the cell type that is most evidently depleted in severe cases of COVID-19. Roan decided to apply her expertise in T cells to understanding how people respond to SARS-CoV-2, the virus that causes COVID-19.
Now, Roan and her team have catalogued the T cells of people who have recovered from mild cases of COVID-19. Their analysis, published in Cell Reports Medicine, sheds light on what a successful immune response to SARS-CoV-2 might entail, and has implications for vaccine development.