January 16, 2021
Environmental Protection Agency
1200 Pennsylvania Avenue, N.W.
Washington, DC 20460
Re: Use of Grignard Pure in air
Dear Sir or Madam:
It is with great concern that I learned of the approval for use of Grignard Pure, or triethylene glycol, in the air in public spaces, as announced here:
epa.gov/newsreleases/epa-ap...
I understand that this idea is well intended, but about 6% of the general population is allergic to glycols. Inhalation of this product will cause anaphylaxis and possible death to these individuals. Glycols should never be aerosolized as this constitutes a threat to public health. Six out of 100 Americans is a great number of us. We stand a better chance of surviving COVID-19 than we do of surviving anaphylactic shock.
Attached please find substantial authoritative documentation of glycol allergy and its severity. Please reconsider and do not allow this substance to be sprayed into the air. At the very least, make it mandatory to post a warning on the doors of areas where this would be done.
Regards,
(redacted)
GLYCLOL ALLERGY ARTICLES
PRACTICE PEARLS| VOLUME 6, ISSUE 6, P2173, NOVEMBER 01, 2018
Polyethylene Glycol: Not Just a Harmless Excipient
Lucinda Kennard, MD, Krzysztof Rutkowski, MD, Rita Mirakian, MD, Annette Wagner, MD
Published: October 03, 2018 DOI:doi.org/10.1016/j.jaip.2018...
jaci-inpractice.org/article...
The Journal of Allergy and Clinical Immunology: In Practice Vol. 7 Issue 7. Polyethylene glycols and polysorbates: Two still neglected ingredients causing true IgE-mediated reactions. Gianfranco Calogiuri, MD, PhD, Caterina Foti, MD, Eustachio Nettis, MD, Elisabetta Di Leo, MD, PhD, Luigi Macchia, MD, Angelo Vacca, MD. DOI: doi.org/10.1016/j.jaip.2019... jaci-inpractice.org/article...
The Journal of Allergy and Clinical Immunology: In Practice. Vol. 7. Issue 6. Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis. Pedro Giavina-Bianchi, MD, PhD, Jorge Kalil, MD, PhD. DOI: doi.org/10.1016/j.jaip.2019... jaci-inpractice.org/article...
The Journal of Allergy and Clinical Immunology: In Practice. Vol. 8, Issue 4. Anaphylaxis to PEGylated liposomal echocardiogram contrast in a patient with IgE-mediated macrogol allergy. Matthew S. Krantz, MD, Yiwei Liu, PhD, Elizabeth J. Phillips, MD, Cosby A. Stone Jr., MD, MPH. Published: January 16, 2020 DOI: doi.org/10.1016/j.jaip.2019... jaci-inpractice.org/article...
The Journal of Allergy and Clinical Immunology: In Practice. Vol. 2 Issue 3. Macrogol hypersensitivity reactions during cleansing preparation for colon endoscopy. Stefano Pizzimenti, MD, Enrico Heffler, MD, Elena Gentilcore, MD, Claudia Bussolino, MD, Franco Nebiolo, MD, Giovanni Rolla, MD. Published:March 31, 2014. DOI: doi.org/10.1016/j.jaip.2014... jaci-inpractice.org/article...
The Journal of Allergy and Clinical Immunology: In Practice. VOLUME 7, ISSUE 5, P1533-1540.E8, MAY 01, 2019. Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized. Cosby A. Stone Jr., MD, MPH, Yiwei Liu, PhD, Mary V. Relling, PharmD, Andrew Abreo, MD, Jonathan A. Hemler, MD, Elizabeth J. Phillips, MD. Published: December 14, 2018. DOI: doi.org/10.1016/j.jaip.2018... jaci-inpractice.org/article...
Jover Cerdá, V., Rodríguez Pacheco, R., Doménech Witek, J. et al. Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary. Allergy Asthma Clin Immunol 15, 9 (2019). doi.org/10.1186/s13223-019-... aacijournal.biomedcentral.c...
Wylon, K., Dölle, S. & Worm, M. Polyethylene glycol as a cause of anaphylaxis. Allergy Asthma Clin Immunol 12, 67 (2016). doi.org/10.1186/s13223-016-... aacijournal.biomedcentral.c...
Polyethylene Glycol Allergy Implicated in Lubricant Intolerance. Leroy, Kyley DO; Farrell, Ronan MD; Kerner, Caroline MD, MSC. American Journal of Gastroenterology: October 2017 - Volume 112 - Issue - p S974. journals.lww.com/ajg/Fullte...
Physician's Weekly. Hypersensitivity to Polyethylene Glycols & Polysorbates. Posted by Rebecca Rice | Dec 30, 2019. physiciansweekly.com/hypers...
And the Allergen Winner Is: Propylene Glycol! Jeannette Y. Wick, RPh, MBA, FASCP. Published Online: Friday, January 19th, 2018. contemporaryclinic.pharmacy...
Contact Allergy to Propylene Glycol and Cross-Reactions. Scheman, Andrew MD; Roszko, Karolina BS. Dermatitis: 11/12 2018 - Volume 29 - Issue 6 - p 350-351. doi: 10.1097/DER.0000000000000416 journals.lww.com/dermatitis...
Dermatologist. Focus on Propylene Glycol. Volume 21 - Issue 8 - August 2013. the-dermatologist.com/conte...
Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid. Clinical and Translational Allergy, 2017; 7: 2 ncbi.nlm.nih.gov/pmc/articl...
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives. Angewandte Chemie, International Edition, Vol 49, Issue 36. onlinelibrary.wiley.com/doi...
Allergy to Macrogols (Polyethylene Glycol). From Ask the Expert: American Academy of Allergy Asthma & Immunology, 3/6/2013. aaaai.org/ask-the-expert/pr...
Anaphylaxis following a transvaginal ultrasound. From Allergy Asthma and Clinical Immunology 12(1) · December 2016. researchgate.net/publicatio...
Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets. Allergy: European Journal of Allergy and Clinical Immunology Volume 61, Issue 8, August 2006. onlinelibrary.wiley.com/doi...
Propylene Glycol: An Often Unrecognized Cause of Allergic Contact Dermatitis in Patients Using Topical Corticosteroids. Skin Therapy Letter, Volume 16 Number 5, May 1, 2011. skintherapyletter.com/aller...
Clin Exp Allergy. 2016 Jul;46(7):907-22. doi: 10.1111/cea.12760. Immediate-type hypersensitivity to polyethylene glycols: a review. Wenande E1, Garvey LH1. ncbi.nlm.nih.gov/pubmed/271...
