Search
Search
About
Log in
Join
Experiences with
Afatinib
Posts
Communities
76 public posts
Filter results
EGFR p.L747_T751de
I read some PubMed data that restarting Erlotinib a possibility even with previous resistance and
Afatinib
promising but Oncologist won’t recommend any further treatment and we’re 2 weeks in - he told dad 8 weeks to live. My dad is 89 and of the generation that whatever the Dr says, you accept.
I read some PubMed data that restarting Erlotinib a possibility even with previous resistance and
Afatinib
promising but Oncologist won’t recommend any further treatment and we’re 2 weeks in - he told dad 8 weeks to live. My dad is 89 and of the generation that whatever the Dr says, you accept.
Adaughter
in
The Roy Castle Lung Cancer Foundation
6 months ago
Just a quick question.
Hi everyone and thanks for all your help so far. As the chemo has now stopped working for Martin we are looking for any other options that might be available to give him more time. His MO has organised a liquid biopsy to see if there are any mutations that could be treated, which might help. We
Hi everyone and thanks for all your help so far. As the chemo has now stopped working for Martin we are looking for any other options that might be available to give him more time. His MO has organised a liquid biopsy to see if there are any mutations that could be treated, which might help. We
Believeit
in
Advanced Prostate Cancer
3 months ago
COVID survivors may be at a greater risk of developing Parkinson’s–like symptoms, researchers warn. What to know to protect your health
COVID survivors may be at a greater risk of developing Parkinson’s disease–like symptoms, researchers warn. What you need to know to protect your health
https://finance.yahoo.com/news/covid-survivors-may-greater-risk-170451040.html "The virus was able to infect cells from all the aforementioned
COVID survivors may be at a greater risk of developing Parkinson’s disease–like symptoms, researchers warn. What you need to know to protect your health
https://finance.yahoo.com/news/covid-survivors-may-greater-risk-170451040.html "The virus was able to infect cells from all the aforementioned
Bolt_Upright
in
Cure Parkinson's
8 months ago
Want to take advantage of all our features? Just log in!
Log in
or
Join
Senolytics - “senolytic” drugs, dasatinib (D) and quercetin (Q) disapointing results in small test- Peter Attia
January 13, 2024 COGNITIVE HEALTH & NEURODEGENERATIVE DISEASE Targeting senescent cells for cognitive health With the recent publication of the first clinical trial of senolytics for AD treatment, popular interest in these drugs has swelled, but is the excitement justified? PETER ATTIA
January 13, 2024 COGNITIVE HEALTH & NEURODEGENERATIVE DISEASE Targeting senescent cells for cognitive health With the recent publication of the first clinical trial of senolytics for AD treatment, popular interest in these drugs has swelled, but is the excitement justified? PETER ATTIA
Scout4answers
in
Fight Prostate Cancer
8 months ago
Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "
Some examples are:
[i]
bipolar androgen therapy (
New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "
Some examples are:
[i]
bipolar androgen therapy (
pca2004
in
Fight Prostate Cancer
1 year ago
Trastuzumab Deruxtecan Extends Survival Over Chemotherapy for Patients With HER2-Positive Metastatic Breast Cancer
Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]
third-line treatment of patients with HER2-positive metastatic breast cancer
[/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented
Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]
third-line treatment of patients with HER2-positive metastatic breast cancer
[/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Just in time for Halloween: Not so fast when zapping all those senescent Zombie Cells, as some might actually be your friends.
As with most new insights into the complexities of the human organism, things usually prove to be more complicated that they first seem. Even a cursory look at genetics reveals that in very short order. And for those hoping to use Occam's Razor to make such organic complexity seem simple, it may be more
As with most new insights into the complexities of the human organism, things usually prove to be more complicated that they first seem. Even a cursory look at genetics reveals that in very short order. And for those hoping to use Occam's Razor to make such organic complexity seem simple, it may be more
cujoe
in
Fight Prostate Cancer
2 years ago
dasatinib
started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?
started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?
cmarr
in
CML Connect
2 years ago
? Experience w/ taking Hydroxychloroquine & ADT simultaneously? If so, issues w/ your heart or other side effects? Clinical Trial or Nubeqa?
I've been considering doing a clinical trial or just starting on Nubeqa. The trial includes a pretty high dosage of hydroxychloroquine (HCQ), along with Metformin and Sirolimus. I'm trying to figure out if the trial/HCQ has a significant chance of causing heart disruptions/issues. I am cautious because
I've been considering doing a clinical trial or just starting on Nubeqa. The trial includes a pretty high dosage of hydroxychloroquine (HCQ), along with Metformin and Sirolimus. I'm trying to figure out if the trial/HCQ has a significant chance of causing heart disruptions/issues. I am cautious because
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Oxidative Stress (ROS), Sleep and the Gut Microbiome: Staying Alive
I am just back from a challenging (humbling) multiday backpack in the High Sierras of California. Very beautiful but drought conditions, dry stream water sources made it more difficult. Here is a pre-note on my own regimen: After completing my two phase radiation treatments for oligometastatic PC:
I am just back from a challenging (humbling) multiday backpack in the High Sierras of California. Very beautiful but drought conditions, dry stream water sources made it more difficult. Here is a pre-note on my own regimen: After completing my two phase radiation treatments for oligometastatic PC:
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Help and advice please.
Over the past 2 years I have had
Afatinib
, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.
Over the past 2 years I have had
Afatinib
, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.
sally70
in
The Roy Castle Lung Cancer Foundation
2 years ago
Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?
https://en.wikipedia.org/wiki/Quinazolinone
Other Quinazoline-Containing Drugs:
--
for treatment of cancers resistant to gefinitib and erlotinib. --
Erlotinib
, an anti-tumor agent. --
Lapatinib
for treatment of advanced-stage or metastatic breast cancer.
https://en.wikipedia.org/wiki/Quinazolinone
Other Quinazoline-Containing Drugs:
--
for treatment of cancers resistant to gefinitib and erlotinib. --
Erlotinib
, an anti-tumor agent. --
Lapatinib
for treatment of advanced-stage or metastatic breast cancer.
Hidden
in
Advanced Prostate Cancer
2 years ago
Senolytic Regimens for Treatment-Emergent Senscent Cells
Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory
Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory
MateoBeach
in
Advanced Prostate Cancer
3 years ago
Radiotherapy
Anyway I’m still taking
afatinib
and will wait to see what my blood biopsy shows to see where I go from now Stay safe
Anyway I’m still taking
afatinib
and will wait to see what my blood biopsy shows to see where I go from now Stay safe
Rusty821
in
The Roy Castle Lung Cancer Foundation
3 years ago
A large injection of hope required. Please.
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy
Afatinib
. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy
Afatinib
. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.
sally70
in
Lung Cancer Support
3 years ago
Dasatinib
I was interested to see in the latest from the Mayo: "
Antidiabetic Effects of the Senolytic Agent Dasatinib
" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation
I was interested to see in the latest from the Mayo: "
Antidiabetic Effects of the Senolytic Agent Dasatinib
" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Rash
Hi Iv been on 50mg
afatinib
now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Hi Iv been on 50mg
afatinib
now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Rusty821
in
The Roy Castle Lung Cancer Foundation
3 years ago
Senolytic combo Dasatinib + Quercetin
Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by
Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by
Purple-Bike
in
Advanced Prostate Cancer
3 years ago
Senolytic Supplements: Quercetin and Fisetin
Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons
Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons
Bolt_Upright
in
Cure Parkinson's
3 years ago
Need to stay strong - some hope ? (too early though)
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
John_morris71
in
Cure Parkinson's
3 years ago
1
2
...
4
Next page
Filter results
Clear filters
Posted in
All communities
The Roy Castle Lung Cancer Foundation
22 results
CLL Support
10 results
Advanced Prostate Cancer
9 results
View top 10 communities
Sort by
Most Relevant
Newest