Experiences with

Afatinib

New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "Some examples are: [i]bipolar androgen therapy (

Over the past 2 years I have had Afatinib, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.

Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]third-line treatment of patients with HER2-positive metastatic breast cancer [/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented

As with most new insights into the complexities of the human organism, things usually prove to be more complicated that they first seem. Even a cursory look at genetics reveals that in very short order. And for those hoping to use Occam's Razor to make such organic complexity seem simple, it may be more

https://en.wikipedia.org/wiki/Quinazolinone Other Quinazoline-Containing Drugs: -- for treatment of cancers resistant to gefinitib and erlotinib. -- Erlotinib, an anti-tumor agent. -- Lapatinib for treatment of advanced-stage or metastatic breast cancer.

started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?

I've been considering doing a clinical trial or just starting on Nubeqa. The trial includes a pretty high dosage of hydroxychloroquine (HCQ), along with Metformin and Sirolimus. I'm trying to figure out if the trial/HCQ has a significant chance of causing heart disruptions/issues. I am cautious because

 I am just back from a challenging (humbling) multiday backpack in the High Sierras of California. Very beautiful but drought conditions, dry stream water sources made it more difficult.  Here is a pre-note on my own regimen: After completing my two phase radiation treatments for oligometastatic PC:

Anyway I’m still taking afatinib and will wait to see what my blood biopsy shows to see where I go from now Stay safe

Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory

I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.

Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own

I was interested to see in the latest from the Mayo: "Antidiabetic Effects of the Senolytic Agent Dasatinib" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation

Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by

Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons

Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on afatinib 50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.

Hi I’m on afatinib 50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated

FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson

Hi, Has anyone taken Candilap? Anyone who knows about or has taken Lapatinib?

NSCLung cancer changing to small cell.