Experiences with

Afatinib

I read some PubMed data that restarting Erlotinib a possibility even with previous resistance and Afatinib promising but Oncologist won’t recommend any further treatment and we’re 2 weeks in - he told dad 8 weeks to live. My dad is 89 and of the generation that whatever the Dr says, you accept.

Hi everyone and thanks for all your help so far. As the chemo has now stopped working for Martin we are looking for any other options that might be available to give him more time. His MO has organised a liquid biopsy to see if there are any mutations that could be treated, which might help. We

COVID survivors may be at a greater risk of developing Parkinson’s disease–like symptoms, researchers warn. What you need to know to protect your health https://finance.yahoo.com/news/covid-survivors-may-greater-risk-170451040.html "The virus was able to infect cells from all the aforementioned

January 13, 2024 COGNITIVE HEALTH & NEURODEGENERATIVE DISEASE Targeting senescent cells for cognitive health With the recent publication of the first clinical trial of senolytics for AD treatment, popular interest in these drugs has swelled, but is the excitement justified? PETER ATTIA

New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "Some examples are: [i]bipolar androgen therapy (

Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]third-line treatment of patients with HER2-positive metastatic breast cancer [/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented

As with most new insights into the complexities of the human organism, things usually prove to be more complicated that they first seem. Even a cursory look at genetics reveals that in very short order. And for those hoping to use Occam's Razor to make such organic complexity seem simple, it may be more

started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?

I've been considering doing a clinical trial or just starting on Nubeqa. The trial includes a pretty high dosage of hydroxychloroquine (HCQ), along with Metformin and Sirolimus. I'm trying to figure out if the trial/HCQ has a significant chance of causing heart disruptions/issues. I am cautious because

 I am just back from a challenging (humbling) multiday backpack in the High Sierras of California. Very beautiful but drought conditions, dry stream water sources made it more difficult.  Here is a pre-note on my own regimen: After completing my two phase radiation treatments for oligometastatic PC:

Over the past 2 years I have had Afatinib, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.

https://en.wikipedia.org/wiki/Quinazolinone Other Quinazoline-Containing Drugs: -- for treatment of cancers resistant to gefinitib and erlotinib. -- Erlotinib, an anti-tumor agent. -- Lapatinib for treatment of advanced-stage or metastatic breast cancer.

Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory

Anyway I’m still taking afatinib and will wait to see what my blood biopsy shows to see where I go from now Stay safe

I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.

I was interested to see in the latest from the Mayo: "Antidiabetic Effects of the Senolytic Agent Dasatinib" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation

Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own

Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by

Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons

FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson