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Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "
Some examples are:
[i]
bipolar androgen therapy (
New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "
Some examples are:
[i]
bipolar androgen therapy (
pca2004
in
Fight Prostate Cancer
24 days ago
Help and advice please.
Over the past 2 years I have had
Afatinib
, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.
Over the past 2 years I have had
Afatinib
, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.
sally70
in
The Roy Castle Lung Cancer Foundation
1 year ago
Trastuzumab Deruxtecan Extends Survival Over Chemotherapy for Patients With HER2-Positive Metastatic Breast Cancer
Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]
third-line treatment of patients with HER2-positive metastatic breast cancer
[/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented
Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]
third-line treatment of patients with HER2-positive metastatic breast cancer
[/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented
Hazelgreen
in
SHARE Metastatic Breast Cancer
5 months ago
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Just in time for Halloween: Not so fast when zapping all those senescent Zombie Cells, as some might actually be your friends.
As with most new insights into the complexities of the human organism, things usually prove to be more complicated that they first seem. Even a cursory look at genetics reveals that in very short order. And for those hoping to use Occam's Razor to make such organic complexity seem simple, it may be more
As with most new insights into the complexities of the human organism, things usually prove to be more complicated that they first seem. Even a cursory look at genetics reveals that in very short order. And for those hoping to use Occam's Razor to make such organic complexity seem simple, it may be more
cujoe
in
Fight Prostate Cancer
7 months ago
Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?
https://en.wikipedia.org/wiki/Quinazolinone
Other Quinazoline-Containing Drugs:
--
for treatment of cancers resistant to gefinitib and erlotinib. --
Erlotinib
, an anti-tumor agent. --
Lapatinib
for treatment of advanced-stage or metastatic breast cancer.
https://en.wikipedia.org/wiki/Quinazolinone
Other Quinazoline-Containing Drugs:
--
for treatment of cancers resistant to gefinitib and erlotinib. --
Erlotinib
, an anti-tumor agent. --
Lapatinib
for treatment of advanced-stage or metastatic breast cancer.
Hidden
in
Advanced Prostate Cancer
1 year ago
dasatinib
started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?
started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?
cmarr
in
CML Connect
10 months ago
? Experience w/ taking Hydroxychloroquine & ADT simultaneously? If so, issues w/ your heart or other side effects? Clinical Trial or Nubeqa?
I've been considering doing a clinical trial or just starting on Nubeqa. The trial includes a pretty high dosage of hydroxychloroquine (HCQ), along with Metformin and Sirolimus. I'm trying to figure out if the trial/HCQ has a significant chance of causing heart disruptions/issues. I am cautious because
I've been considering doing a clinical trial or just starting on Nubeqa. The trial includes a pretty high dosage of hydroxychloroquine (HCQ), along with Metformin and Sirolimus. I'm trying to figure out if the trial/HCQ has a significant chance of causing heart disruptions/issues. I am cautious because
GeorgeGlass
in
Advanced Prostate Cancer
10 months ago
Oxidative Stress (ROS), Sleep and the Gut Microbiome: Staying Alive
I am just back from a challenging (humbling) multiday backpack in the High Sierras of California. Very beautiful but drought conditions, dry stream water sources made it more difficult. Here is a pre-note on my own regimen: After completing my two phase radiation treatments for oligometastatic PC:
I am just back from a challenging (humbling) multiday backpack in the High Sierras of California. Very beautiful but drought conditions, dry stream water sources made it more difficult. Here is a pre-note on my own regimen: After completing my two phase radiation treatments for oligometastatic PC:
MateoBeach
in
Advanced Prostate Cancer
11 months ago
Radiotherapy
Anyway I’m still taking
afatinib
and will wait to see what my blood biopsy shows to see where I go from now Stay safe
Anyway I’m still taking
afatinib
and will wait to see what my blood biopsy shows to see where I go from now Stay safe
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
Senolytic Regimens for Treatment-Emergent Senscent Cells
Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory
Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory
MateoBeach
in
Advanced Prostate Cancer
1 year ago
A large injection of hope required. Please.
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy
Afatinib
. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy
Afatinib
. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.
sally70
in
Lung Cancer Support
2 years ago
Rash
Hi Iv been on 50mg
afatinib
now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Hi Iv been on 50mg
afatinib
now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
Dasatinib
I was interested to see in the latest from the Mayo: "
Antidiabetic Effects of the Senolytic Agent Dasatinib
" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation
I was interested to see in the latest from the Mayo: "
Antidiabetic Effects of the Senolytic Agent Dasatinib
" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Senolytic combo Dasatinib + Quercetin
Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by
Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by
Purple-Bike
in
Advanced Prostate Cancer
2 years ago
Senolytic Supplements: Quercetin and Fisetin
Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons
Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons
Bolt_Upright
in
Cure Parkinson's
2 years ago
Makeup
Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on
afatinib
50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.
Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on
afatinib
50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
Face rash
Hi I’m on
afatinib
50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated
Hi I’m on
afatinib
50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated
Rusty821
in
The Roy Castle Lung Cancer Foundation
2 years ago
Need to stay strong - some hope ? (too early though)
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
John_morris71
in
Cure Parkinson's
2 years ago
Lapatinib for Metastasis of BC
Hi, Has anyone taken Candilap? Anyone who knows about or has taken Lapatinib?
Hi, Has anyone taken Candilap? Anyone who knows about or has taken Lapatinib?
Fit59
in
Breast Cancer India
2 years ago
After 10 mnths on Afatinib my tumour regrew.My consultant described it as behaving atypically. Does this mean it has changed to small cell.
NSCLung cancer changing to small cell.
NSCLung cancer changing to small cell.
sally70
in
Lung Cancer Support
2 years ago
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