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Help and advice please.

Over the past 2 years I have had Afatinib, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.
Over the past 2 years I have had Afatinib, immunotherapy, chemotherapy and a trial drug which had a code type name. Happy to pass on names of drugs if anyone wants them.
sally70 profile image
sally70
in The Roy Castle Lung Cancer Foundation

Radiotherapy

Anyway I’m still taking afatinib and will wait to see what my blood biopsy shows to see where I go from now Stay safe
Anyway I’m still taking afatinib and will wait to see what my blood biopsy shows to see where I go from now Stay safe
Rusty821 profile image
Rusty821
in The Roy Castle Lung Cancer Foundation

Rash

Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own
Rusty821 profile image
Rusty821
in The Roy Castle Lung Cancer Foundation
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Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?

https://en.wikipedia.org/wiki/Quinazolinone Other Quinazoline-Containing Drugs: -- for treatment of cancers resistant to gefinitib and erlotinib. -- Erlotinib, an anti-tumor agent. -- Lapatinib for treatment of advanced-stage or metastatic breast cancer.
https://en.wikipedia.org/wiki/Quinazolinone Other Quinazoline-Containing Drugs: -- for treatment of cancers resistant to gefinitib and erlotinib. -- Erlotinib, an anti-tumor agent. -- Lapatinib for treatment of advanced-stage or metastatic breast cancer.
Hidden profile image
Hidden
in Advanced Prostate Cancer

A large injection of hope required. Please.

I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.
I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs.
sally70 profile image
sally70
in Lung Cancer Support

Senolytic Regimens for Treatment-Emergent Senscent Cells

Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory
Previously, I posted on the topic of cellular senescence, "zomby-like" cells that cannot divide but also do not die. They can become SASP cells, Senscent-Associated Secretory Phenotypes, that can promote the growth and progression of processes in other cells, including PC cells by secreting pro-inflammatory
MateoBeach profile image
MateoBeach
in Advanced Prostate Cancer

Makeup

Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on afatinib 50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.
Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on afatinib 50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.
Rusty821 profile image
Rusty821
in The Roy Castle Lung Cancer Foundation

Face rash

Hi I’m on afatinib 50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated
Hi I’m on afatinib 50mg have been ok but Iv got a rash on my face nose is blocked and eyebrows all dried up I look like Iv be burned any ideas how to relieve would be appreciated
Rusty821 profile image
Rusty821
in The Roy Castle Lung Cancer Foundation

Dasatinib

I was interested to see in the latest from the Mayo: "Antidiabetic Effects of the Senolytic Agent Dasatinib" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation
I was interested to see in the latest from the Mayo: "Antidiabetic Effects of the Senolytic Agent Dasatinib" [1] Many men with PCa are pre-diabetic at diagnosis, with some of the symptons of the metabolic syndrome [MetS]. Pre-diabetics do not necessarily progress to diabetes, but androgen deprivation
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

Senolytic combo Dasatinib + Quercetin

Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by
Nalakrats has in two major posts shared fascinating insights on senescence and senolytics, drugs that selectively clear senescent cells. I am most grateful to him for this, which set me off on a journey the results of which I sum up in this post. Senescence has also recently been well reported on by
Purple-Bike profile image
Purple-Bike
in Advanced Prostate Cancer

Senolytic Supplements: Quercetin and Fisetin

Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons
Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products https://healthunlocked.com/cure-parkinsons/posts/146670689/mucoactive-natural-products and laglag and SilentEchoes had some great information at https://healthunlocked.com/cure-parkinsons
Bolt_Upright profile image
Bolt_Upright
in Cure Parkinson's

Need to stay strong - some hope ? (too early though)

FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
John_morris71 profile image
John_morris71
in Cure Parkinson's

After 10 mnths on Afatinib my tumour regrew.My consultant described it as behaving atypically. Does this mean it has changed to small cell.

NSCLung cancer changing to small cell.
NSCLung cancer changing to small cell.
sally70 profile image
sally70
in Lung Cancer Support

Lapatinib for Metastasis of BC

Hi, Has anyone taken Candilap? Anyone who knows about or has taken Lapatinib?
Hi, Has anyone taken Candilap? Anyone who knows about or has taken Lapatinib?
Fit59 profile image
Fit59
in Breast Cancer India

Skin rash

Hi I was diagnosed with stage 4 lung cancer in February and I am now taking afatinib and the tumour has shrunk thank goodness tho now after all this time my arms and stomach have broke out in the “rash” I was told to plaster myself in cetriban but was wondering does anybody have any tips
Hi I was diagnosed with stage 4 lung cancer in February and I am now taking afatinib and the tumour has shrunk thank goodness tho now after all this time my arms and stomach have broke out in the “rash” I was told to plaster myself in cetriban but was wondering does anybody have any tips
Rusty821 profile image
Rusty821
in The Roy Castle Lung Cancer Foundation

Is anyone on Imatinib for Systemic Mastocytosis and has the KITD816V mutation?

Link below says that it is to be used "for disease without the KIT[D816V] mutation". https://www.nice.org.uk/guidance/gid-ta10503/documents/final-scope https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=98850
Link below says that it is to be used "for disease without the KIT[D816V] mutation". https://www.nice.org.uk/guidance/gid-ta10503/documents/final-scope https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=98850
MastoMan profile image
MastoMan
in The UK Mastocytosis Support Group

Started taking Exjade for iron overload from transfusions

Did this for 3 reasons. I am one of a handful of around 20 people taking both drugs with rux maybe one of 10 taking it with with a trial drug as well. Why do I do it? Other patients took the gamble to try rux and imatinib and lost their gamble so I feel I owe my opportunity to them. Pure research. This
Did this for 3 reasons. I am one of a handful of around 20 people taking both drugs with rux maybe one of 10 taking it with with a trial drug as well. Why do I do it? Other patients took the gamble to try rux and imatinib and lost their gamble so I feel I owe my opportunity to them. Pure research. This
skodaguy profile image
skodaguy
in MPN Voice

has anyone been on exjade

You can all see my post from 2 or so weeks ago. I knew shortly after my iron levels were elevated due to transfusions. Ferritin is also an inflammatory marker but my total iron combining capacity has also been rising steadily ( TIBC). I cannot reduce my transfusion dependency as I have gone down to 52
You can all see my post from 2 or so weeks ago. I knew shortly after my iron levels were elevated due to transfusions. Ferritin is also an inflammatory marker but my total iron combining capacity has also been rising steadily ( TIBC). I cannot reduce my transfusion dependency as I have gone down to 52
skodaguy profile image
skodaguy
in MPN Voice

Trying to keep busy

All in all I feel OK will be happier once they restart my Afatinib but until then I just keep chugging on. I have a very talkative dog and cat that keep me company. :)
All in all I feel OK will be happier once they restart my Afatinib but until then I just keep chugging on. I have a very talkative dog and cat that keep me company. :)
nikkidolls profile image
nikkidolls
in The Roy Castle Lung Cancer Foundation

Killing Dormant PCA Cells--->Senolytic Adaptations [Intro Part 1]

This is a follow up to my quest to prevent BCR's and to maim/inactivate sleeping cancer cells, for those men who reach PSA Undetectability with clean scans. There is an underlying theme thru some of my posts that says--->when the treatments stop, it is time to treat. Yes some men continue to treat with
This is a follow up to my quest to prevent BCR's and to maim/inactivate sleeping cancer cells, for those men who reach PSA Undetectability with clean scans. There is an underlying theme thru some of my posts that says--->when the treatments stop, it is time to treat. Yes some men continue to treat with
Nalakrats profile image
Nalakrats
in Advanced Prostate Cancer
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