ianbut

[ianbut]

For what it's worth, apixaban is taken twice daily as it has a shorter half- life than those medications taken once daily. This means it doesn't stay in the body for as long as medication taken once daily. So perhaps that may influence the choice of anticoagulant. If there is a problem with a bleed, at least there is the possibility on apixaban it won't last as long. I suppose that's why I'm happy to accept the twice a day 'inconvenience' of apixaban.

[CDreamer]

Me too.

[Thomas45]

On the one occasion I needed to avoid a bleed prior to an otherwise unforeseen operation to remove my appendix, when taking once a day Warfarin, I was given intravenous vitamin K and antibiotics. After 12 hours, at 2.30 on a Sunday morning, the operation started. As for DOACs, I had a very bad reaction to one which led to me getting Polymyalgia Rheumatica, an auto-immune condition, which took just under 4 years to leave my body.

When I was told that I could then have any anticoagulant that I wanted, I went back to Warfarin. I bought an INR test meter, to help adjust my diet to make Warfarin work. By that I don't mean I avoided greens, but now have greens regularly.

When a new arrhythmia nurse asked why I wasn't on a DOAC, I told her about my bad reaction, and understood why I won't try another DOAC.

[wilsond]

Me too,exactly my thoughts. As I already take a mug full of tablets ( haha) twice a day it's not an issue.

[Ducky2003]

Apixaban actually stays in your system longer than you would think. I asked my pharmacist if it was ok to stop Apixaban for a couple of days so I could take Ibruprofen for horrendous toothache, until I could see the dentist.He said absolutely not as the Apixaban would still be in my system for at least a week, albeit at reducing concentration so would still react with the Ibruprofen.

[Astridnova in reply to Ducky2003]

Gosh, my cardiologist said it was okay to take ibuprofen with apixaban, as long as I ate and didn't use it every day. I was suffering from really terrible neck pain.

[Ducky2003 in reply to Astridnova]

NSAIDs are contraindicated with Apixaban. Big no no so I'm surprised your cardiologist said that....... this is why I ask my pharmacist about meds, rather than doctors. My pharmacist actually said he'd refuse to sell me Ibruprofen 😊.

[Astridnova in reply to Ducky2003]

My cardiologist knew that and so did I. It seemed there was no other solution for the unbearable pain, which was due to pericarditis. I still use ibuprofen from time to time, for arthritic pain, but I don't take the apixaban if I do.

[Ducky2003 in reply to Astridnova]

I was tempted to just take it as my toothache was constant and nothing else touched it but thought it best not too.

[ozziebob]

Your "reasoning" on Apixaban and it's double-dose, presuming you are not a medically trained expert, understandably includes qualifications like "suppose" and "perhaps".

So I can add to this kind of speculation by adding that "perhaps" your idea was also one of the reasons I was offered apixaban after previously suffering unexplained chronic bilateral subdural haematomas. But I can't be sure as no medical "decision maker" has ever bothered to explain the apixaban decision to me.

And I still haven't started the apixaban, for obvious reasons, together with a Chads2 score of 2 for age only.

[Tapanac]

also apixaban has an antidote

[ozziebob in reply to Tapanac]

Not sure that makes it noteworthy.

As I wrote in a reply yesterday ...

"I looked online at various UK Health Authority directives, and while andexanet alfa is approved for reversing anticoagulation from apixaban and rivaroxaban, it is also used off-label for reversing edoxaban".