The NHS SPS - Specialist Pharmacy Service - has published two papers about DOACs. In case they are of interest:
Understanding direct oral anticoagulant (DOAC) interactions (Published 5 January 2024)
specialistpharmacyservice.c...
Managing interactions with direct oral anticoagulants (DOACs) (Published 5 January 2024)
The ability to reply to this post has been turned off.
Lasted 13 hours so far.
From those more conversant with the main accepted science to date - do these change any conventional wisdom on medicine management?
Sorry since we are apparently not allowed to view links anymore I couldn't possibly comment.
The Understanding page shows the cytochromes associated with various DOACs. I could not tolerate Rivaroxaban and Apixaban and see that both are linked to CYP3A4 - have just got Edoxaban and that says:
Edoxaban is weakly metabolised by CYP3A4/5 and is a substrate of P-gp.
(Rather than "mainly".)
And I do have reason to wonder about CYP3A4 so am really quite happy to see that. Maybe it will be OK?
For info:
Rivaroxaban affected my eyesight - fine focus was impaired.
Apixaban affected my feet - a certain numbness. Started to improve when I (inadvertently) ran out. Still not fully resolved but definitely started to get better the moment I stopped taking it.
Entirely personal experiences and only added in case anyone is mildly curious.
In my view - yes. It’s based on research into how different drugs are metabolized.
It also explains why some people have side effects from a/c whilst others don’t and what other compounds interact.
Thanks Carew. I think I'd better stop using Gingko Biloba (I take Apixaban).
thanks for replies.
On your point Bob - are admin or anyone saying links to presumably appropriate science based research shouldn’t be allowed.
That’s what we are attempting to clarify but I guess it depends on your definition of appropriate science based research?
Hello, just to confirm, external links are allowed to be posted, however, please check with the Admin team in advance to posting.
Admin are here to protect misleading information being shared with the wider audience on all our Forums - therefore, just as before, it is important we check the validity of the source and facts for the benefit of others. Having checked these links in this post today, I can confirm they have been given consent.
I thank everyone for their understanding and hope you understand the reasons behind our requests.
Kind regards
TracyAdmin
I don’t think anyone is going to do that Tracy because of all of the reasons given in recent threads.
When you will not disclose criteria for judgement of what is or not ‘valid’ it smacks of censorship and a closing down of subjects that you think shouldn’t be discussed but are of interest to some members.
You took 2 of my links down but not this one - please explain the difference? Is anything from NHS site ok but not from eg:- Mayo Clinic?
Would Dr Gupta’s excellent video explanation on Nattokinase a ‘valid’ link?
When FJ’s link by Prof Schilling gets removed and this one doesn’t we are naturally upset and extremely worried about your aims.
Is the blanket ban of insisting on screening to ease your workload or to gag discussions on controversial but very valid subjects - such as academic enquiry on how the x5 stroke risk figure came into being?
An explanation of the purpose of this very recent CHANGE in forum ‘guidelines’ would be welcome.
Best wishes
What is the quickest way to get link approvals TraceyAdmin, phone, email, private message? and how long will we wait for a reply.
Please contact either Katrina or myself via the 'Chat' function, we monitor the Forums on a daily basis (Monday-Friday) we will respond at our earliest convenience.
I suggested using Contact Us because that avoids the need to decide which of you to contact. Effectively, it sends PM to all admins/moderators.
Is that a bad idea?
'Contact us' or 'Chat' to either Katrina or I is the best form of contact.
Thank you for the links, Carew - this is the type of good information which helps to keep us safe. I have saved and printed the interactions sheet - some of which my cardiologist warned me about. He also told me to avoid anything with St John's Wort in it (I take Apixaban).
My personal experience of Rivaroxaban was that it was the straw that broke the camel's back. My body reacted to it with an auto-immune condition, that was Polymyalgia Rheumatica, which took nearly four yeave to leave my body, needing a very, very, slowly reducing dose of prednisolone.I then had a choice, to try another DOAC or go back to Warfarin. I bought my own INR meter and went back to Warfarin. My INR soon stabilised.
Thank you Carew, you seem to have more information than I have, I've not seen any list of who can approve links just "Admin".
These are what I am going by:
Please remember to send a message to me [Katrina-Admin] or TracyAdmin so that we may review the link before posting on the forum.
healthunlocked.com/afassoci...
Please note, if links are posted without Admin consent, they will be removed. If you have any questions or would like to contact one of the Admin team, please feel free to contact: info@afa.org.uk
The ability to reply to this post has been turned off.
Peer-Reviewed report by Dr Wolf (Wolf Mini Maze).
Have NICE guidelines for tooth extraction changed?
Hair Loss and Anticoagulants 
