The Understanding page shows the cytochromes associated with various DOACs. I could not tolerate Rivaroxaban and Apixaban and see that both are linked to CYP3A4 - have just got Edoxaban and that says:
Edoxaban is weakly metabolised by CYP3A4/5 and is a substrate of P-gp.
(Rather than "mainly".)
And I do have reason to wonder about CYP3A4 so am really quite happy to see that. Maybe it will be OK?
Rivaroxaban affected my eyesight - fine focus was impaired.
Apixaban affected my feet - a certain numbness. Started to improve when I (inadvertently) ran out. Still not fully resolved but definitely started to get better the moment I stopped taking it.
Entirely personal experiences and only added in case anyone is mildly curious.
Hello, just to confirm, external links are allowed to be posted, however, please check with the Admin team in advance to posting.
Admin are here to protect misleading information being shared with the wider audience on all our Forums - therefore, just as before, it is important we check the validity of the source and facts for the benefit of others. Having checked these links in this post today, I can confirm they have been given consent.
I thank everyone for their understanding and hope you understand the reasons behind our requests.
I don’t think anyone is going to do that Tracy because of all of the reasons given in recent threads.
When you will not disclose criteria for judgement of what is or not ‘valid’ it smacks of censorship and a closing down of subjects that you think shouldn’t be discussed but are of interest to some members.
You took 2 of my links down but not this one - please explain the difference? Is anything from NHS site ok but not from eg:- Mayo Clinic?
Would Dr Gupta’s excellent video explanation on Nattokinase a ‘valid’ link?
When FJ’s link by Prof Schilling gets removed and this one doesn’t we are naturally upset and extremely worried about your aims.
Is the blanket ban of insisting on screening to ease your workload or to gag discussions on controversial but very valid subjects - such as academic enquiry on how the x5 stroke risk figure came into being?
An explanation of the purpose of this very recent CHANGE in forum ‘guidelines’ would be welcome.
When something doesn't make logical sense to me and seems to be a make-work for all concerned, I ask myself 'who benefits?' Corporate agreements? Vested interests?
Please contact either Katrina or myself via the 'Chat' function, we monitor the Forums on a daily basis (Monday-Friday) we will respond at our earliest convenience.
Thank you for the links, Carew - this is the type of good information which helps to keep us safe. I have saved and printed the interactions sheet - some of which my cardiologist warned me about. He also told me to avoid anything with St John's Wort in it (I take Apixaban).
My personal experience of Rivaroxaban was that it was the straw that broke the camel's back. My body reacted to it with an auto-immune condition, that was Polymyalgia Rheumatica, which took nearly four yeave to leave my body, needing a very, very, slowly reducing dose of prednisolone.I then had a choice, to try another DOAC or go back to Warfarin. I bought my own INR meter and went back to Warfarin. My INR soon stabilised.
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