Inhaled Flecainide promising for returning pts with AF to normal rhythm

[Bagrat]

medscape.com/viewarticle/97...

I know many of you are members of Medscape and it is free to join.

If you aren't excerpt below.

NEW YORK (Reuters Health) - Inhaled flecainide shows promise for returning patients with recent-onset atrial fibrillation (AF) to sinus rhythm, a new study suggests

"Inhaled flecainide converts patients to sinus rhythm at a much lower - read 'safer' - plasma concentration compared to oral or intravenous treatments," said Dr. Crijns, a cardiologist at Maastricht University Medical Center in the Netherlands. A lower concentration of flecainide is possible via inhalation because the drug is absorbed from the lungs into the pulmonary venous system, which flows to the heart's left atrium, where atrial fibrillation often occurs."

N.B. The trial was sponsored by InCarda Therapeutics Inc., which is developing inhaled flecainide for paroxysmal AF. Several of Dr. Crijns' coauthors have financial ties to the company.

SOURCE: bit.ly/36v4XNn Circulation: Arrhythmia and Electrophysiology, online February 24, 2022.

[BobD Volunteer]

Have a bit of a problem snorting those pills!

[Bagrat in reply to BobD]

What I thought Bob . Apparently nebulised at low dose but my one concern is the funding for the study!!!

[saulger in reply to Bagrat]

I wouldn't be too concerned. Most pharmacological studies are sponsored. The speed at which an episode is resolved (8 minutes on average) would be the issue for me, and doing so with a lower dosage of Flecainide.I now take 100mg Flecainide and 1.25mg Bisoprolol (both PIP) once I feel an episode emerging. Thanks for the link.

[dmac4646 in reply to saulger]

The lower does is interesting as many are told that if you get an episode to take 200 mg ( max 300 in 24 hours) to get it stopped and with most people it takes 2-3 hours to work - why should a low does return such fast results is it due to entering the blood stream faster ?

[saulger in reply to dmac4646]

Yes, it seems to be more direct as it doesn't need to pass through the stomach, and the quicker you catch an episode, I find, the sooner it resolves. I've had some (not many) stop after less than 30mins, and others (again, not many) lasting almost eight hours. The average last three to four hours.

[saulger]

Very interesting. Thank you.

[KMRobbo]

What a neat idea!

[Bagrat]

It does say "recent onset" AF but I would say worth a crack for anyone with PAF if no structural changes????