Bisoprolol: What is your effective dosage?

[AnnieKato]

My daughter had Ventricular Ectopy (PVCs) and borderline of Heart Failure.

-Initially they gave her Bisoprolol 2.5mg/day. Her PVCs burden went down from 25% to 12%.

-Then they increased the dose to 5mg/day hoping that it'd lower further the number of PVCs. Unfortunately, it swung up to 22% (!).

-Back to 2.5mg and PVCs went down to 10%

-Now, one year later, her PVCs goes up to 27% !!!

Did you experience something like that?

What is your effective dosage? For what condition?

Thanks,

[Ppiman]

I took bisoprolol for flutter and fibrillation, and I recall reading a large study that showed how the effects of bisoprolol were not linear, i.e. a doubling of the dose did not equate to any kind of doubling of effect. In my own case, even 1.25mg produced a marked effect on my heart rate and blood pressure to the extent that in no way would I call that a "small dose".

Steve

[ETHEL103 in reply to Ppiman]

Yes 1.25 was too mu H for me too. My heart rate dropped to below 40at night shown on my fit bit also my heart rate was so slow a walk I could do before Bisoprolol I was panting like a 90 year old. Doc explained as the heart was beautifully slow it couldn't let me do any form of exersiseI have just been changed to Carvedilol and take half of the smallest dose. So far so good.

[Ppiman in reply to ETHEL103]

Let’s hope that does the trick. When I had really low heart rate l, it was not a good experience for me at all and sent my anxiety levels through the roof, too.

Steve

[AnnieKato in reply to Ppiman]

We just had a video conference with Cardiologist this morning. Surprisingly, he suggests to increase to 5mg although it doesn't work in the past. He said:

-Bisoprolol 2.5mg is a small dose !!! What happened in the past is a coincidence (?)

-Bisoprolol is good for heart failure. Her heart rate is in the 40, but she doesn't experience any side effect so 5mg would be fine.

I have no choice but to listen to him. Like you said, 1.25mg is too much for most people in this forum. However, in the US, unfortunately, Bisoprolol 5mg is the smallest dose in the market. My daughter has to cut it in half to get 2.5mg. It's impossible to get 1.25mg. I guess, in each country, doctors have diffident protocol to treat patients.

I'll post the update after her taking 5mg. Hopefully, she'd be fine like he said

[Ppiman in reply to AnnieKato]

It’s not satisfactory, is it? Bisoprolol is a good beta blocker though. From what I’ve read all basic beta blockers are essentially similar in the way they act (except sotalol).

“Heart failure” is a poor term, too. It sounds much worse than it most often is and creates lots of unnecessary anxiety. It’s mainly an entirely reversible condition, I believe.

Steve

[daithelife]

I cannot comment on dosages and never would as they can vary so much from person to person. However, I will say that I could not get on with Bisoprolol. Everyone reacts differently to different beta-blockers and my advice, for the little it is worth, just keep explaining and trying the alternatives.

[Beeflower]

I’ve just started taking them so I’m on 1.25mg so won’t know yet if I need higher dose

[01maxdog]

I'm on 10mg and am fine with it , over 8 years now, some of us can take it , some can't