I've had AF for about 21 years, first paroxysmal, now persistent. Up to 2 months ago my only medication for persistent, with a heart rate of about ninety beats per minute, was Warfarin. While in hospital to have my appendix out I was put on a beta-blocker, Bisoprolol 2.5mg a day. The immediate benefit was my heart rate went down, and I can no longer feel my heart beating, as I did for the 21 years I've had AF. I noticed one side effect early, getting out of breath quicker than I normally do, but I can live with that. The other side effects came on after a month, skin rashes and itching. They're driving me up the wall. Daily antihistamines take off the worst of the itching, but I get rashes and some itching daily. According to the patient leaflet for Bisoprolol 1 to 10 people in 10,000 users of Bisoprolol get rashes and itching. I know I mustn't stop taking Bisoprolol, except under medical guidance. There are other beta-blockers. Does anyone know if all beta-blockers have the same side effects? I've not had them in the past as I have had asthma for at least 43 years (I'm 72). I'm seeing my GP on Friday this week. The photo is one fairly mild rash on my fore-arm. I get rashes everywhere apart from my neck, face, and feet. They come and go, and itch.