I read that Sotalol has an elimination half life of 10-20 hours. On a 12 hourly dosing regime, it appears the trough levels are around half the peak levels.
Before ablation I was a mixed though primarily vagal afibber. Four years after ablation I have clear adrenergic AF every day, about 6 hours total most days. Very little between 1800 and 0600. Get out of bed then it's in and out of AF all day on trivial exertion. Not that it bothers me that much.
It seems to me I could reasonably set the alarm to 0400 to take my Sotalol 120 mgs and have the second dose at say 1200.
Is there an obvious flaw in this argument?
Obviously I could just try and see. I was hoping someone could explain the pharmacodynamics of Sotalol dosing, including varying dose intervals and amounts tailored to the symptoms of the individual patient. The science of steady state, peaks and troughs in the context of Sotalol half life is beyond me now.
Maybe ILowe and ectopic1 will call by later.