Xarelto or apibaxan?

[Arveno]

if you could choose which one would you choose and why? Thank you for your comments.

Yes, I know that everything must be done after discussion wid doc or other competent person.

[meadfoot]

I have taken xarelto for the past three years without side effects or incidence of any kind. At the time I was prescribed it it was the NOAC of choice at my health authority. Taken once daily I find it easy to accommodate, it must be taken with food which enables it to be absorbed well into the system I am told be medics.

More recently our health authority has switched to Apixaban as the NOAC of choice. Not sure why other than it is taken twice daily and maybe it keeps topped up that way but I am just guessing.

Unless I have any contra indications or someone medically qualified tells me to change I will continue as is.

I am sure your medics will help you make the NOAC decision which is right for you,

[Arveno in reply to meadfoot]

Thank you meadfoot for sharing your experience. My dc and 3 doc, friends belive that it is OK to use whichever. Dabigatran has antidot while Xarelto and apixabann yet not. May be apixaban may have antidot in close future.

[Buffafly]

My cardiologist suggested Xarelto and I've been happy with it, not good at remembering pills so one with dinner is easy! I have a chronic bowel problem that often causes trouble in the morning so for me it is a good choice.

[Finvola]

My cardiologist prescribed Apixaban 3 years ago - his drug of choice as he felt it had a lower bleed factor than the others available. I couldn't give an opinion then as I knew absolutely nothing but I am content on it and have no reason to seek a change.

I take it twice daily and the only dietary restriction is anything containing St John's wort. All anticoagulants may interact with other drugs but this can be checked with a pharmacist or doctor.

[Plai in reply to Finvola]

I believe you shouldn't have grapefruit either with apixaban. And avoid herbal remedies as their interactions have not been tested.

[Arveno]

Thank you Finvola. Interesting is your cardiologist remark concerning lower bleed factor. I catch something sillar t following reference:

Effectiveness and Safety of Dabigatran, Rivaroxaban, and Apixaban Versus Warfarin in Nonvalvular Atrial Fibrillation,

Xiaoxi Yao, Neena S. Abraham, Lindsey R. Sangaralingham, M. Fernanda Bellolio, Robert D. McBane, Nilay D. Shah, Peter A. Noseworthy

Journal of the American Heart Association. 2016;5:e003725

Originally published June 13, 201:

"Apixaban was associated with reduced risk of stroke or systemic embolism compared with warfarin (hazard ratio [HR] 0.67, 95% CI 0.46–0.98, P=0.04). The reduction was driven mainly by the lower risk of hemorrhagic stroke (HR 0.35, 95% CI 0.14–0.88, P=0.03).

Dabigatran was associated with similar risk of stroke or systemic embolism compared with warfarin (HR 0.98, 95% CI 0.76–1.26, P=0.98). No significant differences were found in the risk of ischemic stroke or hemorrhagic stroke, but the risk of hemorrhagic stroke was numerically lower in dabigatran patients (HR 0.56, 95% CI 0.30–1.04, P=0.07).

Rivaroxaban was associated with similar risk of stroke or systemic embolism compared with warfarin (HR 0.93, 95% CI 0.72–1.19, P=0.56). No significant differences were found in the risk of ischemic stroke or hemorrhagic stroke, but the risk of hemorrhagic stroke was also numerically lower in rivaroxaban patients compared with warfarin (HR 0.61, 95% CI 0.35–1.07, P=0.08) (Figure 2)."

[Dodie117]

I changed from warfarin to apixiban. I chose apixiban after reading lots of stuff but have now forgotten the details. As apixiban is taken twice daily it leaves the system quicker in the event of accident/bleeding. I think they were all pretty similar but i am happy with my choice and no side effects.

I suspect you will be fine on any if the noacs.

I had no problems with warfarin just fed up of testing, watching green veg intake etc..

[Arveno in reply to Dodie117]

Thank you all for sharing. Even if my husband does not have any problems with Xarelto so with next weeks new subspription we will ask for exchange Xarelto to Apixaban.

[dizzielizzie1 in reply to Arveno]

Hi Arveno, I asked my GP last week if I could change from Rivaroxaban to Apixaban as the latter is gentler on the stomach, I believe and I have had problems with gastritis in the past. She said that in Gloucestershire the CCG has chosen to go with Rivaroxaban and she could not prescribe Apixaban without asking the senior partner if it was allowed. I believe they are about the same price, so I cannot see why there is a problem. Whatever happened to putting the patient's welfare first? I hope you don't have the same problem.