Read the paper linked below for the full scoop… but it seems very positive indeed for a certain subset
Praful Ravi at Dana Farber asks…
Can oligometastatic prostate cancer be cured with ‘total therapy’? Check out our paper reporting on outcomes after fixed-duration ADT +/- ARPI, met-directed therapy and local therapy (if de novo) for omHSPC
At a median of 3yrs after completing a median of 2yrs of systemic therapy, 45% of patients remained progression free and off therapy. Median time to resume therapy was 4yrs. Hint at potential durable long-term remission (and possible cure) with this approach.
Supports ongoing deintensification trials in selected mHSPC patients who achieve an excellent response to therapy, and future trials need to explore fixed-duration therapy in this space. @AtishChoudhury @DanaFarber_GU @DanaFarberNews
Thank you for sharing. This is my exact situation. Recently diagnosed as T3bN2M1b oligometastatic. When we first learned of the 2 bone mets, we were devastated and thought there was no hope. Then met with both Dr. Mark Scholz and my oncologist who both used the word "curative." We said we thought that wasn't an option, but they both explained that, especially at my young age, an aggressive triplet approach (ADT, brachy therapy, SBRT, then docetaxel) there is an "excellent chance at a cure" even though it is late stage. So I am clinging to this sliver of hope for a possible cure at best, and long-term remission at worst.
My treatment included three PSMA PET scans, two surgeries and ADT. First surgery in 2017 to remove the prostate and anything visibly affected. Then a second surgery two years later to remove lymph nodes spotted in a second PSMA scan. A rising PSA in late 2020 lead to starting ‘doublet’ therapy…new at the time…of Lupron and abiraterone. The third PSMA scan was in January of this year that showed that the bone met in my hip socket was gone and there was no evidence of cancer. For now I appear to be cancer free and am off all meds! Checkups every four months. I feel that PSMA PET scans saved my life and were so important in my treatment decisions. Early in my treatment they were not covered by insurance but it was thousands of dollars well spent.
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18F-sodium fluoride PET-CT appeared to be a more accurate identifier of bone metastases in patients with prostate cancer. 
The TheraPb clinical trial of targeted alpha therapy for prostate cancer is running for three years with plans for up to 100 patients
