Lu177: Hi everyone,I'm busy going... - Advanced Prostate...

Advanced Prostate Cancer

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Lu177

Beesnbonsai profile image
6 Replies

Hi everyone,I'm busy going though Lu177 infusions, 2 weeks after the 2nd round and my first psma scan on the 20th August, I have low psa even though I have progression and my doctor is concerned its not working,I can only assume this is because of the creeping up of psa, my question is where do I go if the 177 isn't working?? Cheers Gaz

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Beesnbonsai
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ARIES29 profile image
ARIES29

In this country (Australia) it is very expensive so if it does not work do not proceed with it. I am not a doctor but that is what I did anyway & went back to ADT.

Yank66 profile image
Yank66

MO said he still had options if Pluvicto didn’t work-carboplatin being one chemo. Radiologist said Xofigo was an option. Actinium is being also tested and available in clinical trials.

Cenerus profile image
Cenerus

Does low PSA correlate with low PSMA? It's the PSMA antigen that Pluvicto wants to stick to. Did they do a PSMA PET scan before starting treatment to assess the potential for uptake of Pluvicto. Most of the other radioligand treatments in early testing currently rely on PSMA as well. There is one out of Australia by Clarity using Cu-67 that seems less sensitive to low PSMA. The Actinium based treatments all look interesting. There is also an Astatine based treatment being worked on in Japan that looks good as well. Lots of early trials that are moving from phase I to phase II. So maybe you can get into one of the phase II trials.

Beesnbonsai profile image
Beesnbonsai in reply to Cenerus

Hi no my pet psma showed very avid uptake, which is why they put forward 177,my psa has never been crazy high, 10.7 when diagnosed,and has never gone higher than that, a jump of 3 on the first round of 177 for me is a big jump, my doctor seems to be waiting for a large spike then a drop?? I have requested to be on the actinium trial at the royal marsden if the 177 doesn't work,I am eligible for it.

dk73 profile image
dk73

after 4 rounds this treatment was stopped. Many new Mets in skeleton and higher PSA. He is now doing chemo - Jevtana - PSA has gone from 235-49 after 5 rounds

NewGame profile image
NewGame

What SE’s have you had from the LU-177? I had dose one this past Tuesday. I was knocked out for 3 days and still feel unwell, and have intense breakthrough pain.

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