Small lesion replacing marrow

[Amadeus71]

Fellow Warriors - I had an MRI recently because I was feeling a dull pain/discomfort in my upper left thigh. That started about 6 weeks ago, and is really only noticeable when I do squats. One of the findings from the MRI was "Small marrow replacing lesion is noted involving the left iliac bone medial to the acetabulum." Anyone else have experience with a lesion replacing marrow? How was it treated?

[God_Loves_Me]

It is my personal opinion.

I think you had multiple SBRTs. Have you talked to your radiation oncologist about SBRT again? Also, try to find out systemic therapy; you had chemo in 2017, so maybe it is time for another systemic therapy, which can be another chemo, pluvicto, radium 223, or Clinical trials like ADC, Immunotherapy that has min to zero side effects.

I would start with clinical trials and keep other options in my pocket for the future.

[Amadeus71 in reply to God_Loves_Me]

Much appreciated. The chemo in 2017 was for non-hodgkin lymphoma. I haven't had docetaxel yet. I like the idea of clinical trial.

[God_Loves_Me in reply to Amadeus71]

clinical trials that focus on systemic therapy is the key for all discussion with MO.

Here is the recent clinical trials with promising results.

healthunlocked.com/advanced...

[Amadeus71 in reply to God_Loves_Me]

Thank you!

[swwags in reply to Amadeus71]

"Some people participate in clinical trials because none of the standard (approved) treatment options have worked, or they are unable to tolerate certain side effects. Clinical trials provide another option when standard therapy has failed. Others participate in trials because they want to contribute to the advancement of medical knowledge."

Your body your choice but personally I'll avoid clinical trials unless my treatments under SOC fail. 9 years on for me. Yes I've had marrow replacing tumors. They've been treated both wit SBRT and chemo.

[Amadeus71 in reply to swwags]

Congrats on 9 years! I appreciate your clinical trials perspective. When you had SBRT, was it for just one or two lesions, or several?

[swwags in reply to Amadeus71]

I've had it done a few times, both one and two lesion treatments

[Tall_Allen]

Docetaxel may curtail its invasiveness and usually works wonders on lung lesions too.

[Amadeus71 in reply to Tall_Allen]

Thank you TA!

[SeosamhM]

"Anyone else have experience with a lesion replacing marrow?" Yes - I've had multiple bone lesions at multiple times, most with bone marrow involvement. It is a fairly common occurrence with aPCa, affecting the red marrow in flat bones or the spongy-matrix areas of long bones .

[Amadeus71 in reply to SeosamhM]

8 years and multiple treatments - I will gladly accept your input. Thank you for sharing!