FDA grants Fast Track Designation to ONCT-534 for mCRPC

[DrawingSnowmen]

urologytimes.com/view/fda-g...

[DrawingSnowmen]

Here's the trial, Nebraska, Texas and Virginia:

clinicaltrials.gov/study/NC...

[spencoid2]

this explains what ONCT-534 is I had no idea prior to finding this. is this something to get excited about? i am headed toward Pluvicto kicking and screaming. might this be a better option?

oncternal.com/pipeline/onct...

[DrawingSnowmen in reply to spencoid2]

The ONCT-534 isn't available except in the trial and it's a phase 1/2, so it's completely unproven although it looks promising. Pluvicto has clinical trials behind it so if you need it now I would think that would be the more logical choice.

[spencoid2 in reply to DrawingSnowmen]

the problem is that i do not know how much i really "need" pluvicto. my PSA is doubling at .9 months but who knows why and if this will continue. i also do not know if the fairly small radiographic progression is something to worry about or not. the PSMA scan might reveal more about how much and where. i can tolerate the bone pain with a little morphine but am worried if that will spread and increase in intensity and how fast. obviously i need to do something but how critical is it that i act quickly? i have an appointment for an opinion from a third oncologist. she is supposed to be very knowledgeable about everything PC related and is not affiliated with UCSF I trust Dr. Aggerwal and do not think he is just pushing a UCSF one size fits all but another opinion can not hurt.