Husband's biopsy shows prostate cancer metastatic to liver

Hi all,

I had asked a question a few weeks back regarding my husband Scott's liver lesions. He is 70, stage IV with metastatic prostate tumors to his bones, and now he has a few in his liver as well. He had a biopsy of the liver lesions a week ago and it shows prostate adenocarcinoma spread to his liver. His doctor was concerned about small-cell cancer, which apparently is a very fast-moving cancer, but thankfully Scott tested negative for that.

Scott had been on Xtandi for the previous two years, and then the last year or so he has been undergoing Pluvicto treatments. But after the 4th treatment he seemed worse than before, so I guess we can assume Pluvicto was not the treatment for him? It has been postponed for the immediate future.

We are very thankful the biopsy did not show the small-cell cancer his doctor was concerned about. But we don't know what to expect at this point.

Can you folks who have been down this road give us an idea what to expect? Is Scott nearing the end of his battle, or is there still hope?

Thank you!!

[Muffin2019]

I am in the same boat, it is normal prostate cancer not the small cell aggressive kind, a blessing at least. Chomo with doxetol to see if it works, had one but will not know until blood work next Tuesday with a second treatment the following day. They have a referral to radiology, maybe a treatment using radiation or a combo of chemo and radiation. I am in good health otherwise and not ready to give up at 71. I wish him the best, stay strong and fight onward.

[Hidden in reply to Muffin2019]

Thank you for your response. Much appreciated. Hope you do well!

[GP24]

You can use SBRT radiation for liver mets: ro-journal.biomedcentral.co...

[Hidden in reply to GP24]

Thank you. I will check out that link.

[Rrrspc in reply to GP24]

Is SBRT acceptable when there are a lot of small lesions?

[Tall_Allen]

Has he had cabazitaxel and Provenge?

[Hidden in reply to Tall_Allen]

No, he hasn't been prescribed anything yet. He started with Xtandi then went to Pluvicto. It took them four weeks just to get the biopsy scheduled and another week for the results. He was getting ready to have Pluvicto #5 but he has been taken off of that. We have a consult with his doc on Monday afternoon.

[Hidden]

My brother was on Xtandi for a year and a half with bone (spine) metastasis, when he started to get some pain on his left side. CT and ultrasound did not show spread in October/ November 22, but in Feb 23, there was evidence of spread to the liver, with both hips ( pelvis) engaged. Radiation was given to reduce the pain, with results evident after 2 weeks. Chemo was also started after radiation- docetaxel, but worsened his condition and stopped after 2 treatments. The next CT showed spread to the lungs, with inflammation to the pancreas.

My brother's cancer was very aggressive. I do think doing chemo early would help more, than in this latter stage. Maybe they can look at a different chemo drug. I t is worth a try before he gets very weak.

[Hidden]

I'm so sorry about your brother, that sounds terrible! Scott had metastatic tumors on most of his bones for a long time, but no organ involvement. His PSA was pretty low while on Xtandi. But it seems like everything got worse when he started the Pluvicto. He now has more bone lesions than before, and of course now has liver lesions. He has lost a ton of weight and is weak and feels awful. It would appear that Pluvicto did not work for him like it does for others. We have a consult with his doctor on Monday at noon to figure out a game plan. If the plan is chemo I will definitely ask about the chances of it worsening his condition!

[Hidden]

I picked up an endometrial tumor over my prostate (mutation) and it was still localized to the region. Bladder Complications were Hell but the tumor itself responded really well to radiation, carbotoxel and Docetaxel. There is hope!

[Hidden]

Glad it worked well for you! We find out at noon today what the doc has planned.