The Stampede trial showed 2 years ADT plus abiraterone is more effective in controlling the cancer than ADT alone if the cancer had extended to local lymph nodes.
There are many discussion about continuous versus intermittent treatment. As a layman, I have no medical expertise to base my thought. Here is my clinical history. In conversations with Mayo, Dr. Kwon, he was amenable to coming off treatment - the six cycles of taxotere, 18 months of Lupron and 25 IMPRT to the PLNs based on my response. I think the key to that decision is having clinical criteria to do so, a plan to actively monitor while off treatment - labs, consult and imaging, then criteria for going back on treatment.
The decision at the time to do the triplet therapy was in part based on the STAMPOEDE and CHAARTERED trials, in part Dr. Kown's methodology of combining treatments and brining them forward vice linear and sequential.
I have been off treatment for roughly 4-1/2 years. During that time I had labs and saw my urologist very 2-6 months. Our criteria was three or more consecutive PSA tests showing an increase. We have now met that criteria and he has order imaging, Plarify - pylarify.com/patient/about?...
When we see those results, my medical team - urologist, radiologist and oncologist and I, will make a decision.
As I said, I am a study one one, it was my decision in conjunction with the support of my medical team. Did it change the outcome, Overall Survival, don't know. However, 4-1/2 years off treatment has been quite enjoyable.
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