PIK3CA somatic mutation identified via liquid biopsy

[HopingForTheBest1]

My recent Guardant liquid biopsy report detected PIK3CA Amplification. There are currently no FDA approved therapies available. Appreciate input.

[Tall_Allen]

The only open clinical trial I know of is this one:

clinicaltrials.gov/ct2/show...

Copanlisib is an PI3K inhibitor, already FDA-approved for follicular lymphoma.

[tango65]

Discuss about ipatasertib which has been used along with abiraterone in patients with PTEN loss which also affect the PIK3 pathway

cancer.gov/publications/dic...

thelancet.com/journals/lanc...

[Alexcohen]

Hello - I have a double PIK3CA mutation and started the Tapistry trial last week at Mount Sinai as i'm eligible for inavolisib (GDC-007), which has shown efficacy: mountsinai.org/clinical-tri...

[HopingForTheBest1 in reply to Alexcohen]

Thanks for this info. Do you know which cohort are you in?

[Alexcohen in reply to HopingForTheBest1]

Tapistry Cohort H. See: westcancercenter.org/trials...

[HopingForTheBest1 in reply to Alexcohen]

You have nothing posted in your bio. It would be helpful if you would provide and share details.

[Alexcohen in reply to HopingForTheBest1]

I updated my bio -- my details are pretty unique.