Is this new?

[Teufelshunde]

Has anyone seen this yet? Looks interesting to the extent I can understand things.

embopress.org/doi/full/10.1...

[Scout4answers]

Interesting

[Don_1213]

Much too dense for me..

[Hidden]

I couldn't get through all of that but this issue of 'dormancy' is something our excellent contributor Nal has spoken about. I hope he gets to see this paper and can digest it for us.

[Teufelshunde in reply to Hidden]

That would be nice. I have read all his posts on the senolytics and take Fisetin and Chrysin on weekends only. Hope he will be back after his sabbatical. This one is a little over my head.

[noahware]

A dense read for sure, but let's start with this to get an idea of potential practical application:"... loss of tumor-intrinsic type I IFN ... promotes bone cell activation to drive cancer progression" and "HDAC inhibition promoted long-term antitumor immunity, and blocked cancer growth in bone."

Aside from the use of synthetic HDAC inhibitors, how do we inhibit HDAC?

Excerpts from various articles:

"Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, such as broccoli and broccoli sprouts. SFN has been shown to inhibit histone deacetylase (HDAC) activity in human colon and prostate cancer lines. Other dietary agents such as butyrate, biotin, lipoic acid, garlic organosulfur compounds, and metabolites of vitamin E have structural features compatible with HDAC inhibition."

"Allyl derivatives from garlic were among the first compounds described to impact histone acetylation status. Other well-characterized plant HDACi include sulforaphane (SFN) isolated from cruciferous vegetables, and quercetin, found in a variety of fruit."

Others mentioned include curcumin, soy and resveratrol. So this gives another mechanistic explanation of why all these food components might be associated with a slowing of cancer progression, but that of course doesn't mean a given individual will actually benefit from them in terms of his own particular PC.

Eat your broccoli (sprouts)!

[Teufelshunde in reply to noahware]

That was great. Thanks so much. Another reinforcement for sulforaphane (I use BROQ per dose in clinical study). I also do quercetin (with zinc) as covid prophylaxis, curcumin for general health, and garlic powder for heart, bp, etc. Nice to know these may also be helpful for this beast.

[slpdvmmd]

Thanks for posting.