Anyone on or done the triplet ?

[Farn]

How is it working out for you ?

I’ve been offered the opportunity by paying for the docetaxal and as a low volume man is it still as beneficial as high volume ?

Any feedback greatly appreciated

[Tall_Allen]

The only triplet that has been proven beneficial in all men is ADT+chemo+darolutamide (ARASENS). They have not published separate results for men with low volume or high volume of metastases yet. The triplet of ADT+chemo+abiraterone (PEACE1) has only proven beneficial in men with high volume of metastases so far. This doesn't prove that a triplet won't be beneficial in men with low volume of metastases, it just takes longer to prove a benefit, if there is one, because men with low volume of metastases live so long.

Genomics may prove to be a better guide than counting # of metastases. A Decipher Grid Analysis (on the biopsy cores) or detection of genomic mutations in PT53, WNT, and DNA-double strand break repair genes may turn out to be a preferable indicator of potential benefit.

[Farn in reply to Tall_Allen]

Thank you for your explanation it’s always appreciated

[Hopeful129]

My husband is about to start triplet therapy in 3 weeks. He has de novo low volume disease. He he is on ADT and will have 6 rounds of Docetaxel and Daralutomide. Then he will have radiotherapy to prostate and any lymph nodes and small bone met after a couple of months. Off the back of the Peace and Arasens and Peace Trials his oncologist wants to him hard with intense early treatment. He is 50 and fit.

[Farn in reply to Hopeful129]

Very best wishes for the best outcome following the results of those very promising trials

[Tall_Allen in reply to Hopeful129]

That is a great plan! Who is his oncologist? Did he get insurance approval?

[nonm in reply to Tall_Allen]

Thanks, T_A.....for asking the questions for us

[Hopeful129 in reply to Tall_Allen]

We live near London. My husband has health insurance and I realise we are fortunate to have more options. Everything has been a steep learning curve since husbands shock diagnosis ( found randomly in health check, no symptoms). I found this site while looking up as much information as I could to help him.

[ishitasen]

Usually, the Docetaxal is prescribed in the high volume disease. It has been found to prolong survival and improves a range of outcome measures, including time to metastatic progression and subsequent therapy. There is a significant paucity of published data in the literature, in patients with low volume metastatic prostate cancer and Docetaxal is associated with significant side effects. It would be advisable to have a detailed discussion with your treating physician regarding the usefulness of Docetaxel in your scenario.

[Farn in reply to ishitasen]

Thank you very much for taking the trouble to give your opinion and advice in regard to my advanced prostate cancer current status,It is appreciated.