your results don't indicate an increased genetic risk of hereditary cancer.
No genetic mutations were identified
Genes analyzed:
APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p14ARF), CDKN2A (p16INK4a), CHEK2, EPCAM, GREM1, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53
Not sure if this is good or bad news as some of the newer drugs seem to be more effective if you have a mutation.
Thoughts?
I took this test and had the same result. I spoke with one of their counselors. I view it as good news as I took the test for the sake of my son and grandson. Basically we don't carry any of these mutations so it was not the cause of the cancer. Having said that, finding out the DNA of your tumor (if you have one) aka somatic test, would likely help in choices of treatment going forward. Thanks for posting.
Color and Guardant tests test for the same genetic anomalies BUT
Color tests the genes you were born with, and Guardant tests what your prostate cancer genes have evolved to.
You want both tests.
Was this a blood test or a solid tumor test (from biopsied material) ? I can't imagine have any gene mutations as a good thing but cannot say that for sure. My solid tumor test came back with 2 hits but neither were actionable at that time or present that I am aware of.
saliva test
It's a germline (heredity test). My MO thought it was good. Great for a baseline and tell your kids. I had this and also the tempus. No hereditary mutations. Good news for my kids and brother.
But to track it you need a somatic test.
My MO wants me to do guardant360 once a quarter. No mutations found in my baseline. The main one that she's looking for is ARV7. It's actionable.
No mutations is good.
I have asked my MO to give me the guardant test and his response was "it won't change out treatment plan, so not worth doing"
Maybe he's not using any therapies that can be affected by known mutations. Perhaps he doesn't plan to do any. If you never have actionable mutations, great. If you do perhaps look into them.
"it won't change out treatment plan, so not worth doing" I heard that concerning Axumin scan and I struggled with it. In hindsight they were correct and saved me $3800-$6200 out of pocket cost.
See my reply to RSH1 above on why it is import in light of new results from PROpel and MAGNITUDE trials on adding PARP inhibitor to abiraterone is very beneficial.
Not there yet but will keep it in mind. Thanks.
Tp53 is now actionable.
More info is better than less.
Today's info may be useful in the future.
You pay for it out of your pocket. Why not take it.
Mine was Tempus. I discussed it with genetic counselor at Kaiser and she said I should do another one with her preferred company but I passed. I will wait for something down the line like a new tumor before checking it again.
If the PC is metastatic then it has progressed enough to have accumulated various significant mutations. Among the important actionable ones are HRR ( homologous DNA recombinant repair) genes such as BRCA1/2 and ATM. Even if you do not have these mutations in germline heredity, they can and do develop in the cancer (somatic). This can be detected in blood test of cell-free tumor DNA by the Guardant 360 test. If HRR mutations are present (and perhaps even if not) then adding a PARP inhibitor to abiraterone can improve PFS and OS. These results were recently released for PROpel and MAGNITUDE studies.
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Thanks Paul for the reports from 2022 ASCO. I will share w my Uro/Onco
It's definitely good news. Mutations in those genes make you more prone to more virulent types of a PCa.
Thanks, good to know although mine was rated 5 (aggressive ) by docs who did my biopsy
Gleason score and genomic tests are independent and test for different things.
What is difference between "Virulent" based on genetic test and "aggressive" based on biopsy. what does that mean for me going forward?
No different. it doesn't mean anything - all that matters is that you have cancer in your lymph nodes. The aggressiveness of your GS 9 cancer in your prostate already happened.
The Biopsy is a measure of your current aggressiveness... basically your current phenotype (best if you look it up).
The genetic tests are a measure of how aggressive it is capable of getting (geneotype) (best if you look it up).
The Color test shows the genes that you were born with.
The Guardian test shows current genes that your prostate cells either started with, or have evolved through mutation.
I think that is a pretty complete statement. As far as it goes.
Had the same result from Color. Does this mean that something like Lu-177 therapy would not work for me?
I think Lutetium needs PSMA scan and has been more effective in lymph node disease.
No it doesn't mean LU177 therapy is not for you. LU177 is a radioligand that will attack and kill PSMA avid tumors. As Grumpyswife indicated, it appears to be more effective on soft tissue but for some it's effective on bone metastases too. That's a different topic though so will leave it at that.
same result for me also. Which i think is good news. Did you ever get a Decipher score? Another piece of information for you
I got the same result.
Same here on negative results for COLOR. Decipher is based on the post surgical material for pathology. It measures the aggressiveness of the PC you have had removed (hopefully).
Color me scared............
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 03/03/2022 6:21 PM EST
Genetic Testing For Advanced Prostate Cancer 
My supplement list and mTor pathways role In metastatic prostate cancer. 
Cisplatin-Vinblastine-Davarbazine chemo for Advanced Prostate Cancer
Genetic test result question
repeat genetic testing
