Anti-fibrotic drugs and Orgovyx combination

[nicecity]

Does anyone have Idiopathic Pulmonary Fibrosis and taking anti-fibrotic drugs such as Ofev or Esbriet AND also have PCa and taking Orgovyx?

I would like to know firsthand experience of such combination of drugs.

Thanks in Advance

[Blackpatch]

I can sort of help a little bit, maybe - I have IPF (early stage, diagnosed in 2019) and have been on OFEV for about a year... the IPF was picked up on a CT reference scan for a a PSMA PET, performed just before eSRT after BCR in mid 2018, following RRP in late 2017.

I am also Decipher hi (0.91 - congrats, you're the first person I've come across with a higher Decipher score!!)

And while I haven't been on Orgovyx, I figured I'd reply because I reckon you aren't going to find many PCa guys with IPF... the most relevant experience I can offer is that I had some breathing problems when I was on Zytiga for 8 months during/after eSRT. My haemoglobin went from ca, 170 down to 145 as a result of the Zytiga and I had a few uncomfortable episodes where I really thought I was in trouble. This was one of the factors that convinced me to drop the Zytiga and just rely on Goserelin for the remaining 4 months of the ADT side of my attempted "cure" post-BCR.

I realise I wasn't on Ofev during the breathing issues and that you're primarily concerned about drug interactions - I can't help you there... but in discussions with your MO, you might want to ask about likely impact on your haemoglobin levels - it was all pretty unpleasant!!

Anyway, T has been back to full strength for over 18 months and I remain undetectable as of last week. Plus, with haemoglobin back up in the mid 150s, I have no breathing issues - so there can be at least some periods of blessed relief amongst all the PCa/IPF crap...

Stuart

[Abcsoup73]

Following this post as my father who is 74 has both IPF and advanced prostate cancer. Would be nice to connect with others who are in this same unique situation!