LU1177 efficiency

[Wakaka]

Hi ALL

After treatment with LU177, do the treated metastases disappear definitively? otherwise they reappear after how long

Best regards

[tango65]

In the Vision trial the radiographic progression free survival was 8.7 months.I had LU 177 PSMA in 2016 and the mets have remained PSMA negative so far. I have been in A DT and Nubeqa for 2 years because PSA increased in 2020. Last PSMA PET /CT was negative in October 2021.

[Wakaka in reply to tango65]

Thank you veryThé answer is vers Clément

I home the same with me

[dhccpa in reply to tango65]

The Mets are still visible, though? Just with no uptake on PET? If you can clarify, I'd appreciate. I wasn't sure if bone Mets ever really disappeared. Thanks

[tango65 in reply to dhccpa]

The mets were in lymph nodes. They were not enlarged in tbe CT scans. Basically, I never had mets in bone scans or Ct scans, only in the PSMA PET/CTs before LU 177 PSMA treatment.

[dhccpa in reply to tango65]

Thanks

[GP24]

It depends on the size of the mets, the dose applied, if you are a good responder and if you add an antiandrogen while being treated which increases the PSMA expression. In my case new mets appeared at different places.

[Tall_Allen]

Some will, some won't

[ARIES29]

I had a good response with LU-177. The PSA was down to 1.6 from 18 but two years later with no ADT treatment it rose to 19.So in my case it gave me two years extra life but it did not cure anything & cost heaps. $10K aud each time.