AMG 757

[Danielgreer]

Is anyone in the AMG 757 trial? If so, can you please share your experiences? Thanks.

[j-o-h-n]

AMG 757 Abstract

Purpose: Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a high relapse rate, limited therapeutic options, and poor prognosis. We investigated the antitumor activity of AMG 757, a half-life extended bispecific T-cell engager molecule targeting delta-like ligand 3 (DLL3)-a target that is selectively expressed in SCLC tumors, but with minimal normal tissue expression.

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 01/29/2022 2:28 PM EST

[Jzner in reply to j-o-h-n]

My brother is researching this trial at the U of C in Chicago. His bone metastasis is spreading after 18 rounds of Cisplatin and Etoposide last year and this year he’s on Docataxel his 5 th of 6, and it doesn’t seem to be effective in reducing the bone Mets. Any info is appreciated. Thank you!

[j-o-h-n in reply to Jzner]

I suggest you re-post here (new day not 2/3/2022) regarding your dear brother....Maybe more eyes will see your post....and you'll get responses....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 02/03/2022 2:068 PM EST

[Jzner in reply to j-o-h-n]

Thank you, I’ll do that!

[Danielgreer in reply to Jzner]

Hi Jzner, my understanding is that the AMG 757 trial requires that a potential subject to not be progressing. Out of curiosity, why is your brother receiving Docetaxel without Carboplatin? I’m assuming he has neuroendocrine cancer he’s trying to control?

[Danielgreer in reply to j-o-h-n]

Hi John, you probably are aware that this trial is for neuroendocrine pc? It worked well for small cell lung cancer and now they are extending it to nepc.

[j-o-h-n]

Thank you..... now I am....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 02/03/2022 7:26 PM EST

[Jzner]

He has scpc. He has Cisplatin last year which is a sister drug of Carboplatin, maybe that’s why he just gets docataxel. His Oncologist at the U of C told him he is a candidate for the trial.

[Dweiss1973 in reply to Jzner]

Did your family member go on AMG 757. My husband has a consult to join the study on May 5 with Dr. Stadler.

[Jzner]

No he did not. He’s on his last infusion of Docetaxel this Monday. Then scans in 3 weeks. He also goes to Dr. Stadler. In maybe in the horizon, but not just yet.