Xtandi: Zyriga failed after eight... - Advanced Prostate...

Advanced Prostate Cancer

22,373 members28,135 posts

Xtandi

scooby0111 profile image
13 Replies

Zyriga failed after eight months and starting xtandi. What can I expect for success and for how long? The list of side effects is scary. Any comments are welcome.

Written by
scooby0111 profile image
scooby0111
To view profiles and participate in discussions please or .
Read more about...
13 Replies
Magnus1964 profile image
Magnus1964

Everyone responds differently meds. I got four years from xtandi.

The side effects of Xtandi are generally a bit more than Zytiga, but I would be more concerned about whether it will work since there is cross-resistance between Zytiga and Xtandi. Switching from one anti-androgen to another generally doesn't work for long, if at all.

That coupled with what appears to be a fairly short time to castrate resistance (although that's an assumption on my part: I don't see your treatment history)

I do think chemotherapy is a better choice for your situation, possibly followed by Xtandi or another anti-androgen.

The CARD trial proved that sequencing in chemotherapy is superior than just switching between anti-androgens.

nejm.org/doi/full/10.1056/N...

Something to discuss with your doctor.

Tall_Allen profile image
Tall_Allen

Better to do chemo in between.

GP24 profile image
GP24

Your doctor prescribed Xtandi because he thinks you will probably try to avoid a chemo. As Gregg wrote, there is a cross-resistance between Zytiga and Xtandi. Therefore Xtandi after Zytiga will work for two to three months only.

in reply toGP24

"Your doctor prescribed Xtandi because he thinks you will probably try to avoid a chemo."

I agree. I'm guessing it's because of the resistance to chemo and most people are fine with just taking a different pill.

I have one of these doctors, but I don't see her. She told me "I put everyone on Xtandi after Zytiga." Fortunately for me, I have another doctor at the VA who says "When Zytiga becomes ineffective, I won't put you on Xtandi because it's unlikely to work for long. You should do Cabazitaxel next." That's the doctor I'm using now.

My husband was on Zytiga for about 15 months then switched to Xtandi and got almost 2 years of benefit. PSA was going up for the last 12 months on Xtandi but it was still doing "something". It really depends on the person and how they respond.He is now back on Xtandi after 10 months of BAT. (Also successful for psa reduction but especially for quality of life.) We hope this second time around is as successful as the first although I have to say, one week of Xtandi and he's back in bed at 8 and fatigued all day.

julyturqsee profile image
julyturqsee in reply to

what is BAT?

in reply tojulyturqsee

Bipolar androgen therapy, also known as high dose testosterone. The treatment cycles through high and low levels of testosterone every 28 days.

julyturqsee profile image
julyturqsee in reply to

thanks for your reply. Can u explain BAT in more detail.? Is it like Estrogen Hormone Replacement? Does it counter ADT? never heard of it

in reply tojulyturqsee

It isn't a common therapy because testosterone was thought for decades to fuel cancer. Many doctors won't do it even though the numbers of men who have tried it are increasinging and the trial doctors believe it is safe. Here is a link with some details (cancertherapyadvisor.com/ho.... You can discuss it with your doctor to see if 1. you are a candidate and 2. if your doctor is on board to try it.

julyturqsee profile image
julyturqsee in reply to

thank you. will read up on it.

larry_dammit profile image
larry_dammit

I started Xtandi after chemo ,Dec of 16. Not sure of all the side effects as I’m on ADT as well. Just watch out when starting new drugs. It does not play well with others.

j-o-h-n profile image
j-o-h-n

Side effects should be called SuicSide effects....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 11/03/2021 6:52 PM DST

Not what you're looking for?

You may also like...

Xtandi

Well I stopped taken Xtandi for 10 days and started on on pill a day for three days then stopped...
roncyn profile image

Xtandi

Well I was on Xtandi for 25 days and PSA went from 6.51 to .61 quite a fast drop! Then I had to...
roncyn profile image

Xtandi

Question on Xtandi, I have been on Xtandi/Lupron for 41 months with a great deal of success....

xtandi

I was diagnosed with Advanced Prostate Cancer in November 2020, my PSA at that time was2600, had it...

Xtandi

well, Zytiga has run it's course and has stopped being effective, I am now going to start Xtandi, I...
MrJack profile image

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.