31 months since prostate removal - and now I am a .1ng/ml

[plato123]

from all your experiences with this is that a long time, normal? what does that mean for prognosis.

3+4 Gleason

5.4 pre-op PSA

all final path, clean margins, no lymph or other

[Tall_Allen]

You can use this to determine your odds that salvage RT will work:

riskcalc.org/ProstateCancer...

[Fightinghard]

I think you have had a good result from surgery. Enjoy life!

[Gemlin_]

Early BCR is associated with poorer oncological outcomes. The majority of BCRs happens the first year. Here is a diagram (from a study) showing risk of biochemical recurrence by the following year after radical prostatectomy (%). SRT is next!

Diagram

[Justfor_]

An isolated PSA value doesn't say much solely by itself. If your 31 months PSA time series has been monotonously ascending, then by extrapolation you can estimate the old, but still generally respected, 0.2 BCR confirmation level. In my case, 0.12 by labA or 0.15 by labB six months later was 0.11 by labA or 0.14 by labB. The 0.1 - 0.2 PSA range is very tricky.

[Teufelshunde]

I was in your exact position only my reoccurance appeared earlier. Went from <.1 (3/19) to high of .36 on 9/20. Was looking at SRT but had to do a hip revision before and then covid delay. I tried some alternate items like fenben and supplements and had lowered my PSA to .29 by 4/21 but decided to to SRT since was not a big downside and some wise words from a MO at Northwestern that basically said, you may have stopped it for now, but cancer is smart and will find another pathway, and doing SRT could be a knock out blow tht at my age and physical shape would be minimal if any. Looked at the SPPORT study results also. Both her and my RO at U Chicago said no need to do ADT since benefit only amounts to fractional percentage at my PSA level and quality of life would suffer. Did oral anyway for a month and decided to end that. Just finished SRT one month ago, no side effects other than having to come off my plant based diet since radiation and fiber dont play well together, especially on a one hour drive each way every day to SRT. One month PSA at .15 but told it should continue to fall.

The one item I wish I had known about before my decision (would have tried this for a few months) was the following double-blinded, randomized, placebo-contolled trial of sulforaphane. Group that took that, which were all seeing rise is PSA after RP, had PSA mean rise of .10 and PSA double time of almost 3 years compared to control at rise of .62 and half the double time. And the exact product they took is available on Amazon now in US under name BROQ (or go to their website) so you can take exact dosage as study. I am taking that now as a prophylaxis in addition to other items along with my 90% plant based diet. Lots of good FB groups that have good info.

Your doc will never tell you about any of these things but I think combination of SOC and other items is better than just relying on SOC. Just my non-medical but well researched $0.02

pubmed.ncbi.nlm.nih.gov/259...