Prostatitus

[lewicki]

Before I was diagnosed for Prostate cancer I was treated for prostatitis. I have read that prostatitis is a precursor to Prostate cancer.

Years later and many different treatments for prostate cancer there has not been any mention of prostatitis for any of my doctors. It just came to me do I still have it and how to test and what might be the treatment ?

Is this why COC prescribes Doxycycline ?

[LearnAll]

Yes..It is now established that chronic Prostatitis leads to prostate cancer. There is no definite way to know if you still have active prostate infection but you can measure level of inflammation in your body by checking C Reactive Protein. If CRP is below 0.5 , it can be assumed that you do not have prostatitis. As for Doxycycline, besides eliminating any infection ,it also blocks other pathway of PCa growth.

[lewicki in reply to LearnAll]

Thanks . Good info. I forgot to mention I still have a prostate without any treatment to it.

[maley2711 in reply to lewicki]

You say you have had many PCa treatments, but still have untreated prostate. Does this mean that you were diagnosed when already metastatic?

[lewicki in reply to maley2711]

No I was first diagnosed in 1999 . I went to St Geog Klinik in Germany and had trans urethral hyperthermia. was not diagnosed metastatic until 2016.

[maley2711 in reply to lewicki]

why did you say you still have untreated prostate?

[lewicki in reply to maley2711]

I still have a prostate. Do not know if it is infected since ADT has shrunk it. If it is infected I should treat it I would think.

[Tall_Allen]

There are no good cures for prostatitis. It is treated symptomatically if there are symptoms.

[lewicki in reply to Tall_Allen]

Could the symptoms be masked with years of ADT resulting in a very small gland. This might affect renewed cancer.

[Tall_Allen in reply to lewicki]

What’s the difference if you have PCa already?

[lewicki in reply to Tall_Allen]

I am on vacation ( hope in long term remission) and thinking if I have infection and since Prostatitis can cause prostate cancer and concerned the infection if still there since I still have a prostate gland then I should address the possibility of infection and treat it ??

[Tall_Allen in reply to lewicki]

You already have PCa. The horse has left the barn.

[Schwah in reply to Tall_Allen]

I thought anti biotics sometimes help prostatitis

Schwah

[Tall_Allen in reply to Schwah]

Rarely. Usually cause resistance. AUA recommends against it.

[acuphealing]

Hello Lewicki! I just came across a good, fairly thorough article in chronic prostatitis: aafp.org/afp/2016/0215/p290... did not mention that prostatitis can be a precursor to PCA- will check that next.

[lewicki in reply to acuphealing]

Thanks

[acuphealing]

According to Mayo Clinic (I consider them a reliable and valid source): no link has been proven between prostatitis and PCA: mayoclinic.org/diseases-con...

[pjoshea13 in reply to acuphealing]

Mayo: "There's no direct evidence that prostatitis can lead to prostate cancer."

& that has been my understanding for 17 years.

If a link had been reliably established, men with prostatitis would surely be warned of the risk - & I don't believe that they are.

On the other hand, an inflammatory condition would be expected to be pro-cancer.

Here is a 2020 meta-analysis:

Correlation between Prostatitis, Benign Prostatic Hyperplasia and Prostate Cancer: A systematic review and Meta-analysis

"Background: No consensus has been reached on the definite associations among prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Hence, this meta-analysis was conducted to explore their triadic relation by summarizing epidemiological evidence. Methods: Systematical and comprehensive retrieval of online databases PubMed, PMC, EMBASE and Web of Science was performed to acquire eligible studies, up to April 1st, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to clarify their correlations. Results: A total of 42 studies were enrolled in the quality assessment and 35 were finally included in the meta-analyses. Among them, 27 studies were included to describe the association between prostatitis and PCa (OR=1.72, 95% CI=1.44-2.06, I2 =90.1%, P<0.001). 21 studies presented significant evidence about the relation between BPH and PCa (OR=2.16, 95% CI=1.75-2.88, I²=97.1%, P<0.001). Due to the huge heterogeneity among studies, those with obvious outliers were excluded based on the Galbraith plots. Ultimately, 17 studies were screened out to assess the association between prostatitis and PCa (OR=1.59, 95% CI=1.48-1.70, I²=29.4%, P=0.123). Meanwhile, 8 studies were retained to evaluate the association between BPH and PCa (OR=3.10, 95% CI=2.87-3.35, I²=8.4%, P=0.365). As for the relation between prostatitis and BPH, a case-control study and a cohort study both supported that prostatitis could enhance the risk of BPH.

Conclusions: Significant correlations were revealed among prostatitis, BPH and PCa. Prostatitis or BPH could lead to escalating risks of PCa. Meanwhile, people with a history of prostatitis might be more vulnerable to BPH."

pubmed.ncbi.nlm.nih.gov/318...

-Patrick

[lewicki in reply to pjoshea13]

Thanks

[Hidden]

Prostatitis was not a precursor for me.

GD

[Daveofnj]

I had several bouts of prostatitis beginning years before being diagnosed with PCa. My Urologist prescribed Cipro and then Levaquin. Both took care of the prostatitis but had side effects. That class of antibiotics now carries an FDA warning.

There are other sites devoted to prostatitis, including a FB group, where you can get much more information.

As another poster mentioned, COC prescribes doxycycline as a repurposed drug to fight PCa.

[Magnus1964]

I was treated for prostatitis be being diagnosed. It was a misdiagnoses.