I wonder if Ga68 PSMA PET/CT is effective in detecting NEPC tumors
Which imaging techniques are used in ... - Advanced Prostate...
Advanced Prostate Cancer
No, it absolutely does not detect it. Why are you asking? Do you have reason to suspect you have it?
Allen, my recent blood test for NSE was elevated (54.6 ng/dl against ref range of <16.3). Chromogranin A test result is pending. LDH is normal
You have to be positive for several blood markers, not just one or two. Biopsy of metastasis and IHC analysis are more definitive. What is FDP PET?
FDG (Fluorodeoxyglucose) PET. My MO thinks we should get the PSMA PET first. If Chromogranin A result comes in positive, then repeat the NSE test and then consider getting some other scan to detect NEPC, if there is any
NEPC will show up on FDG because it is fast-growing; it will not show up on PSMA PET - NEPC does not express PSMA. There is another PET indicator - Ga-68-DOTATATE that will show neuroendocrine of GI origin, but will usually not show neuroendocrine of prostate origin. Biopsy and IHC is the best way to diagnose it.
My lab specifies that it needs the blood frozen for NSE tests. Otherwise the value will be too high. My doctor cannot freeze the blood so I no longer worry about elevated NSE.
For neuroendocrine tumors you could get a 68Ga-DOTATOC PET/CT.
NSE result was well above the limit (55 vs 16). I will retest in a different lab making sure that they handle the blood properly. Do you get other NEPC tests regularly?
I get a CGA test sometimes but NSE is of no value in my case as mentioned in my post. CGA is the main marker but you need more than one to begin testing for neuroendocrine cancer.
I know a patient who went to the lab and had is blood drawn there. This resulted in a normal NSE value.
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