The much-maligned natural supplements that have been widely discussed here are mostly polyphenols. Polyphenols are separated into families, of which the flavonoids are one. Chalcones belong to that family. Its cousins include anthocyanidins, flavones, isoflavonoids & others. Over 5,000 natural flavonoids have been identified, so it is a vast subject.
The characterization of polyphenols is based on structure. For bicyclic chalcones, apart from the phenyl component, there must be two rings in the structure. Perhaps Nalakrats has more to say on that.
"Several natural and (semi) synthetic chalcones have shown anti-cancer activity due to their inhibitory potential against various targets namely ABCG2/P-gp/BCRP, 5α-reductase, aromatase, 17-β-hydroxysteroid dehydrogenase, HDAC/Situin-1, proteasome, VEGF, VEGFR-2 kinase, MMP-2/9, JAK/STAT signaling pathways, CDC25B, tubulin, cathepsin-K, topoisomerase-II, Wnt, NF-κB, B-Raf and mTOR etc." [1]
As some know, or have been told by those who know, polyphenols either don't work or are dangerous. (Except perhaps. when a pharmaceutical company has tweaked one & is selling it to us for $1,000 / month.)
Meanwhile, the happily ignorant (I include myself) will be interested that:
"Chalcones are absorbed in the daily diet and appear to be promising cancer chemopreventive agents. Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. This family possesses an interesting spectrum of biological activities, including antioxidative, antibacterial, anti-inflammatory, anticancer, cytotoxic, and immunosuppressive potential.
"Compounds of this family have been shown to interfere with each step of carcinogenesis, including initiation, promotion and progression. Moreover, numerous compounds from the family of dietary chalcones appear to show activity against cancer cells, suggesting that these molecules or their derivatives may be considered as potential anticancer drugs." [2]
IMO it is unlikely that diet alone will supply a chalcone load large enough to have therapeutic benefit for men with advanced PCa.
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