Parp Inhibitors - what are the risks? - Advanced Prostate...

Advanced Prostate Cancer

20,782 members25,887 posts

Parp Inhibitors - what are the risks?

pjoshea13 profile image
2 Replies

Back in 2017 there was a paper from Duke, NC:

"Acute Myeloid Leukemia After Olaparib Treatment in Metastatic Castration-Resistant Prostate Cancer"

"Poly(adenosine diphosphate-ribose) polymerase (PARP) in- hibitors exploit defects in DNA repair to induce tumor-selective cytotoxicity and are in clinical development for treatment of pros- tate cancer. However, these agents may have lethal toxicities. This report highlights a serious adverse event after the use of a PARP inhibitor for a patient with metastatic castration resistant prostate cancer. Our patient had a complete response on olaparib treatment for prostate cancer, but developed likely treatment-related acute myeloid leukemia. Long term safety monitoring will be necessary in discussing clinical risks and benefits of PARP inhibitors for patients with genetically susceptible tumors."

I don't recall it creating a stir.

Now we have a French study [2] (not PCa-specific):

"Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database"

"The incidence of myelodysplastic syndrome and acute myeloid leukaemia across PARP inhibitor groups was 0·73% (... 21 events out of 4533 patients) and across placebo groups was 0·47% (... three events out of 2774 patients)."

Although the risk factor is 2.63, the numbers are very small. The added risk is only 0.26% (1 in 385). But something to be aware of.

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/287...

[2] thelancet.com/journals/lanh...

Written by
pjoshea13 profile image
pjoshea13
To view profiles and participate in discussions please or .
Read more about...
2 Replies
cesces profile image
cesces

Nice catch.

j-o-h-n profile image
j-o-h-n

I would gladly comment but you see right now I'm inhibited to do so.....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 12/30/2020 6:10 PM EST

You may also like...

PARP inhibitors - which one?

different PARP inhibitors all currently in trials for prostate cancer treatment, including...

Any experience with PARP inhibitors (Niraparib)?

radiation treatment and hormone therapy for the past 2 years. He has now become castrate resistant...

BRCA And Parp inhibitors

germaine and in a sample tumor. I was able to gain access to a PARP inhibitor Rucaoarib,but...

Adding PARP inhibitor (Olaparib) to the Standard Therapy (Zytiga/ADT/Prenosone)

that adding Olaparib BEFORE cancer cells can form large colonies and become castrate resistant...

FDA Approves First PARP Inhibitor Rucaparib for BRCA-mutated metastatic castration-resistant prostate cancer

proval-rucaparib-brca-mutated-metastatic-castration-resistant-prostate This article explains why the