Hello!
Here is a potentielly stupid question, but bear with me. Provange is a ”vaccine”? Then how come it seems uncommon for HSPC and be avalaible first when one is CR?
Thank you!!
Provange: Hello! Here is a potentielly... - Advanced Prostate...
Provange
Written by
TheTopBanana
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3 Replies
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Drugs are almost always tested and approved first for the patients who need it most and for whom results will be available first.
Provenge was tried in recurrent men, and early results were equivocal:
clincancerres.aacrjournals....
Provenge is in trials for use with Active Surveillance:
clinicaltrials.gov/ct2/show...
Prostate cancer is immunologically cold. Only Provenge so far has had any effectiveness as a monotherapy. Optimal timing is not necessarily earlier - it may have more benefit later when there are more cancer antigens, but not too late to do any good.
Especially in these times, this is a great question, TTB! Provenge can be seen as a vaccine in that it attempts to train our immune system to target PCa cells - think putting a bloodhood on a scent. Unfortunately, even old Scooter the Hound can't pick up a trail all of the time - that's what TA means by "cold tumor"!
I was not aware that Provenge was being studied with Active Surveillance - now THAT should be an interesting study once the data is in.... Likely 2025+.
Great question actually. There is no reason not to suspect that Provenge could be more beneficial if given earlier when HSPC, over the longer span of disease progression. And perhaps with a booster after a few years. The deflection of the curve of progression is not as steep. Meaning it may be more than just 18 or 24 months to become statistically significant. I hope they follow up in the guys on TAs reference study. It would be good if HS men had access to it being covered.
