Luminal Adenocarcinoma

[Jmr11820]

On my DECIPHER GRID genomic profile summary, my molecular signature states Luminal (as opposed to basal) adenocarcinoma. Can someone tell me the significance of luminal vs basal?

[Tall_Allen]

Here's what I have in my file:

clincancerres.aacrjournals....

[Jmr11820 in reply to Tall_Allen]

Apparently responds favorably to ADT but the GRID tells me my ADT response rate is 23. I think maybe I just should quit looking at the grid. Thank you for sharing that study. Take care.

[Jmr11820]

Thanks for your response. I’m seeing differences in subtype A and B in terms of aggressiveness. This DECIPHER report doesn’t appear to distinguish the two. Appreciate your help!

[Jmr11820]

Thanks again

[Jmr11820]

Looking at ASCO post from May 2017, say luminal B carries a worse overall prognosis than A and basal but B responds best to post op ADT. Kind of a mixed bag. That said, DECIPHER won’t tell me what mine is. Hmmm.

[Jmr11820]

ncbi.nlm.nih.gov/pmc/articl...

FYI.....