Increasing PSMA

[Blair77]

Hi,

I believe I read on here about taking Xtandi or Enzalutamide to increase PSMA activity? Does anyone recall something like that?

Thanks

[Hidden]

Here's an article on the subject:

ascopubs.org/doi/full/10.12...

From the article: Of importance, PSMA expression is increased on androgen deprivation and is highest in high-grade and castration-resistant prostate cancer (CRPC).

[Tall_Allen]

Yes, but it's a temporary increase, lasting at most 3 months. After that, the PSMA expression is reduced.

[Napper01]

I’ve been on Xtandi/Enzalutamide for 4+ years and after six months my PSA dropped to 0.01 and has remained there since. Hoping for this to continue of course! 😁

[Lt036 in reply to Napper01]

Hello Napper01, I am also on Xtandi along with Lupron shots. Only been on Xtandi 6 months and my psa is down from 2 to.8. My question is how are your side effects? Can’t imagine 4 years of feeling like I do since I started Xtandi. Seems like I have every side effect except seizures and weight loss although I could use some weight loss. Just feel like crap most of the time. Appreciate your response.

[Napper01 in reply to Lt036]

Indeed I have/do feel poorly most of the time, with me it’s weight gain and fatigue like I have never known. About two years in I got down and dirty with my onco about the fatigue suggesting I could not continue working, travelling. He reduced my Xtandi dose 25% (4 caps to 3 caps daily) experimentally and with no change in PSA levels this helped. In addition I began a fitness regime of walking 3-4 kms a day, turned my diet into a healthy one, changed my Xtandi dose to 6:00 pm to sleep through some of the side effects...it does get better and I’m still alive!

[Yogi8]

Good news about xtandi was very little side affects. While I know it works for many men it did not work for me. I’m now on erleada. Not sure that’s working any better. Good luck and God bless