ADT & CVD

[pjoshea13]

Short video on the topic.

ADT leads to the metabolic syndrome [MetS], or a worsening of MetS. For men with cardiovascular issues, this can increase the risk of another CV event.

Bertrand Tombal mentions that in men with CVD history, one in three on ADT will experience a CVD event.

{Dr Bertrand Tombal, Chairman of Urology at Cliniques Universitaires Saint Luc (Brussels, Belgium), is also a Professor of Urology at the Université Catholique de Louvain.}

youtube.com/watch?v=KCPrckS...(Not working as expected?)

-Patrick

[pjoshea13]

An earlier segment of the above session:

youtube.com/watch?v=GMmML0Q...(Not working as expected?)

-Patrick

[6357axbz]

Good Morning to you Patrick...

[cesces]

There are two types of cardiovascular issues you can have.

Inclusions that block an artery

And

Strokes caused by arterial leakage.

Does androgen deprivation therapy affect one or both?

Does anyone have an answer to this question?

[pjoshea13 in reply to cesces]

There are countless studies connecting MetS to CVD. [1] [2] [3] & [4] are papers that have MetS/CVD/ADT in the title.

For specific mention of stroke, transient ischemic attack, deep vein thrombosis & pulmonary embolism, see [5]

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/188...

"Men with prostate cancer may be at increased risk for metabolic syndrome, cardiovascular disease, and diabetes from androgen deprivation therapy (ADT)."

[2] ncbi.nlm.nih.gov/pubmed/190...

"We found that the increased risk for serious cardiovascular disease becomes evident within months of beginning ADT."

[3] ncbi.nlm.nih.gov/pubmed/212...

"ADT, presumably at least in part owing to low testosterone levels is associated with insulin resistance, the development of metabolic syndrome plus increased overall and cardiovascular disease mortality."

[4] ncbi.nlm.nih.gov/pubmed/214...

"This study suggests that patients under ADT show higher prevalence of metabolic abnormalities and cardiovascular risk similar to those found in morbidly obese subjects. It is possible that both processes share cardiovascular risk through metabolic syndrome."

[5] ncbi.nlm.nih.gov/pubmed/309...

"We observed an increase in the risk of stroke, TIA {transient ischemic attack}, and DVT {deep vein thrombosis} in men receiving ADT and an increased risk of PE {pulmonary embolism } in men receiving long-term ADT. These results highlight concerns regarding long-term risks of ADT on stroke and thromboembolic events in the treatment of PC."

[cesces in reply to pjoshea13]

Perhaps I'm missing something here, but they all seem to talk about various types of arterial blockage, but not about arterial leaks.

Correct?

[pjoshea13 in reply to cesces]

There are no PubMed hits for <prostate "arterial leaks">

[cesanon in reply to pjoshea13]

LOL,

1. Medical terms for "arterial leaks" would include

Hemorrhagic Stroke

Hemorrhagic CVA

Hemorrhagic

When hemorrhaging affects the brain the result can be much more life affecting than prostate cancer.

2. Is there any reason to believe that there is any linkage between ADT and hemorrhaging?

3. Have you ever heard of any relationship? Being on blood thinner I was hoping you would be fairly knowledgeable about the subject.

Does that not become an issue to pay attention to when you take blood thinners?

[pjoshea13 in reply to cesanon]

It's a common belief that "blood thinners" thin the blood, but they merely inhibit coagulation. This is not dangerous if one can avoid accidents for the rest of one's life. LOL. Many die every year because they bleed out due to traumatic injury.

I use nattokinase because it dissolves the fibrin of unwanted clots & does not interfere with the coagulation cascade. Paper cuts do not faze me.

IMO, the ADT-->MetS-->CVD journey does not increase the risk of hemorrhage.

-Patrick

[cesanon in reply to pjoshea13]

OK, thanks

[Hidden]

Estrogen therapy (instead of Lupron) helps with CV risk. Also helps with bone loss. Either way though, QOL is affected. Perhaps less with estrogen but still lots of negatives.

I was on estrogen therapy for 5 months. T was undetectable. Zero libido, massive muscle loss, also lost a decent amount of fat though, no depression. Now I'm on a high T protocol. Might do BAT sometime but I love the T. QOL means a lot.

Edit: I also took zytiga. Zytiga blocks cancer production of testosterone. Combo got me to 0.

[Christopherg]

I have a pacemaker, does ADT affect me?

Sorry for the dumb question...

Thanks. Chris

[pjoshea13 in reply to Christopherg]

Hi Chris,

No dumb questions here.

I can't find any reference to a potential issue. But you should check with your cardiologist. ADT will worsen symptoms of the metabolic syndrome & I can't say how that will affect you.

Best, -Patrick

[Christopherg]

Thank you so much Patrick.

Best regards, Chris