Need Info on AR-V7 Gene

[Hotcars74]

I have had a gene test, and found that I dont have the ar-v7 gene, and need some info on what that means for my hormone treatment, currently on lupon only, Ga68 psma scan showed mets to T-6 & L-2 ( oligometastatic )

[Hidden]

It's definitely positive, but I don't think it means a lot for you right now. You are going to stay on ADT which is working for you now and that's the most important thing.

AR-V7 is positive in less than 1% of primary PCa. It becomes much more prevalent after castrate resistance. It's important when you are looking at the effectiveness of second-line ADT drugs like Zytiga or Xtandi, but should not be an exclusion for trying them.

AR-V7 is something that usually develops as a result of pressure from treatment so you will need to have this checked again after you become castrate resistant.

[Hotcars74 in reply to Hidden]

ty, gregg57, I have appointment with MO this Friday, he mentioned going on xtandi before I had my scans two months ago now he's talking zytiga instead ??

[Hidden in reply to Hotcars74]

I've been on Zytiga for just over a year now and haven't noticed any side effects. It's keeping my PSA undetectable. Can't argue with that.

[Tall_Allen]

That's good news. It's only bad news if you do have it.

[Hotcars74 in reply to Tall_Allen]

ty Tall Allen, I have alot of respect for you and others on this site, and read all the post, and take notes to learn as much as I can