Lyparnza

[elainea53]

I a clinical trial. It is randomized. We will know if we get it in about a month. I have not found any info on this helping pc and my husband does not have the Brca gene,

He has another gene p53 I think. Not sure if the lyparnza is the best next treatment. Does anyone know about it.

[tango65]

Lynparza could work in patients with mCRPC with BRCA, ATM, CDK12 and PALB2 mutations.

urotoday.com/conference-hig...

I am not aware that Lynparza works in cancers with the p53 mutation. This complex article has, in Table 1, a list of possible agents which could work in cancers with p53 mutations.

ncbi.nlm.nih.gov/pmc/articl...

Perhaps, you could discuss with the MO if any of them is being used in a clinical trial.

[elainea53 in reply to tango65]

Thanks. I wonder why he is in this trial. It’s at mdandersen

[tango65 in reply to elainea53]

Best of luck.

[elainea53 in reply to tango65]

He was in the trial before p53 was found

[Tall_Allen]

p53 is probably the most common mutation - nothing for it yet. There is hope that PARP inhibitors may work in situations beyond BRCA mutations. It seems that response to carboplatin is prognostic that a PARP inhibitor (as maintenance therapy) may prove useful.

[Nachas613]

nature.com/articles/s41391-...

[elainea53 in reply to Nachas613]

I just noticed your user name. I am also one of the tribe.