Lyparnza: I a clinical trial. It is... - Advanced Prostate...

Advanced Prostate Cancer

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Lyparnza

elainea53 profile image
7 Replies

I a clinical trial. It is randomized. We will know if we get it in about a month. I have not found any info on this helping pc and my husband does not have the Brca gene,

He has another gene p53 I think. Not sure if the lyparnza is the best next treatment. Does anyone know about it.

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elainea53
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tango65 profile image
tango65

Lynparza could work in patients with mCRPC with BRCA, ATM, CDK12 and PALB2 mutations.

urotoday.com/conference-hig...

I am not aware that Lynparza works in cancers with the p53 mutation. This complex article has, in Table 1, a list of possible agents which could work in cancers with p53 mutations.

ncbi.nlm.nih.gov/pmc/articl...

Perhaps, you could discuss with the MO if any of them is being used in a clinical trial.

elainea53 profile image
elainea53 in reply to tango65

Thanks. I wonder why he is in this trial. It’s at mdandersen

tango65 profile image
tango65 in reply to elainea53

Best of luck.

elainea53 profile image
elainea53 in reply to tango65

He was in the trial before p53 was found

Tall_Allen profile image
Tall_Allen

p53 is probably the most common mutation - nothing for it yet. There is hope that PARP inhibitors may work in situations beyond BRCA mutations. It seems that response to carboplatin is prognostic that a PARP inhibitor (as maintenance therapy) may prove useful.

Nachas613 profile image
Nachas613

nature.com/articles/s41391-...

elainea53 profile image
elainea53 in reply to Nachas613

I just noticed your user name. I am also one of the tribe.

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